OBJECTIVE: The purpose of this study was to evaluate histologic findings and outcomes among adolescents with cervical dysplasia. STUDY DESIGN: Patient charts (2001-2005) were reviewed. Prevalence of cervical intraepithelial neoplasia (CIN) grades 2 and 3 and progression and regression were recorded. RESULTS: Five hundred one patients were identified. On biopsy, 324 patients (65%) had CIN 1 or less, and 177 patients (35%) had CIN > or = 2. Twenty-nine percent of the patients with CIN 2 opted for conservative treatment vs excision. Over 18 months, the condition of 65% of the patients regressed; the condition of 20% of the patients was stable, and the condition of 5% of the patients progressed without cancer. Of the patients who underwent excision (follow-up median, 26 months), 84% experienced regression of their condition; the condition of 11% was persistent, and 5% progressed with no cancer. CONCLUSION: CIN > or = 2 is present in 35% of our cohort. Most had CIN 2, and most experienced regression. Our observation supports continued vigilance in the evaluation of adolescents but suggests that less intervention for CIN 2 may be acceptable.
OBJECTIVE: The purpose of this study was to evaluate histologic findings and outcomes among adolescents with cervical dysplasia. STUDY DESIGN:Patient charts (2001-2005) were reviewed. Prevalence of cervical intraepithelial neoplasia (CIN) grades 2 and 3 and progression and regression were recorded. RESULTS: Five hundred one patients were identified. On biopsy, 324 patients (65%) had CIN 1 or less, and 177 patients (35%) had CIN > or = 2. Twenty-nine percent of the patients with CIN 2 opted for conservative treatment vs excision. Over 18 months, the condition of 65% of the patients regressed; the condition of 20% of the patients was stable, and the condition of 5% of the patients progressed without cancer. Of the patients who underwent excision (follow-up median, 26 months), 84% experienced regression of their condition; the condition of 11% was persistent, and 5% progressed with no cancer. CONCLUSION:CIN > or = 2 is present in 35% of our cohort. Most had CIN 2, and most experienced regression. Our observation supports continued vigilance in the evaluation of adolescents but suggests that less intervention for CIN 2 may be acceptable.
Authors: Alan G Waxman; David Chelmow; Teresa M Darragh; Herschel Lawson; Anna-Barbara Moscicki Journal: Obstet Gynecol Date: 2012-12 Impact factor: 7.661
Authors: Lisa Beth Spiryda; Kara M Whitaker; Amy Messersmith; Carolyn E Banister; Kim E Creek; Lucia A Pirisi-Creek Journal: J Low Genit Tract Dis Date: 2016-01 Impact factor: 1.925
Authors: L Stewart Massad; Charlesnika T Evans; Gypsyamber D'Souza; Teresa Darragh; Howard Minkoff; Donna Henry; Lakshmi Goparaju; Laila I Muderspach; D Heather Watts Journal: J Low Genit Tract Dis Date: 2008-07 Impact factor: 1.925