Literature DB >> 17688444

ISN1 nucleotidases and HAD superfamily protein fold: in silico sequence and structure analysis.

Bharath Srinivasan1, Hemalatha Balaram.   

Abstract

cN-II class of 5' purine nucleotidases exhibit specificity for IMP/GMP and belong to the HAD (haloacid dehalogenase) superfamily of hydrolases. The recently identified ISNI class of IMP specific 5'-nucleotidases occurring in yeast, fungi and certain Plasmodia lack sequence homology with the cN-II class of enzymes. We show from analysis of motif and fold conservation that ISN1s also belong to the HAD superfamily. This identification adds a new novel member to this superfamily.

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Year:  2007        PMID： 17688444

Source DB:  PubMed          Journal:  In Silico Biol        ISSN： 1386-6338


  5 in total

1.  Phosphoglycolate phosphatase is a metabolic proofreading enzyme essential for cellular function in Plasmodium berghei.

Authors:  Lakshmeesha Kempaiah Nagappa; Pardhasaradhi Satha; Thimmaiah Govindaraju; Hemalatha Balaram
Journal:  J Biol Chem       Date:  2019-01-30       Impact factor: 5.157

2.  Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila.

Authors:  Bharath Srinivasan; Farhad Forouhar; Arpit Shukla; Chethana Sampangi; Sonia Kulkarni; Mariam Abashidze; Jayaraman Seetharaman; Scott Lew; Lei Mao; Thomas B Acton; Rong Xiao; John K Everett; Gaetano T Montelione; Liang Tong; Hemalatha Balaram
Journal:  FEBS J       Date:  2014-02-17       Impact factor: 5.542

3.  Identification, Heterologous Expression, and Functional Characterization of Bacillus subtilis YutF, a HAD Superfamily 5'-Nucleotidase with Broad Substrate Specificity.

Authors:  Natalia P Zakataeva; Dmitriy V Romanenkov; Yuliya R Yusupova; Victoria S Skripnikova; Takayuki Asahara; Sergey V Gronskiy
Journal:  PLoS One       Date:  2016-12-01       Impact factor: 3.240

4.  Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.

Authors:  Loïc Carrique; Lionel Ballut; Arpit Shukla; Neelakshi Varma; Resmi Ravi; Sébastien Violot; Bharath Srinivasan; Umesh Tippagondanahalli Ganeshappa; Sonia Kulkarni; Hemalatha Balaram; Nushin Aghajari
Journal:  Nat Commun       Date:  2020-06-26       Impact factor: 14.919

5.  Expression of bovine cytosolic 5'-nucleotidase (cN-II) in yeast: nucleotide pools disturbance and its consequences on growth and homologous recombination.

Authors:  Simone Allegrini; Daniela Nicole Filoni; Alvaro Galli; Anita Collavoli; Rossana Pesi; Marcella Camici; Maria Grazia Tozzi
Journal:  PLoS One       Date:  2013-05-17       Impact factor: 3.240
  5 in total

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