PURPOSE: To evaluate the concentration of sFas in tear film of cystic fibrosis patients. MATERIAL AND METHODS: Tear samples were collected from 20 patients with cystic fibrosis and 20 patients from control group. The sFas levels were determined by immunoenzymatic assay ELISA. RESULTS: We found statistically increased levels of sFas in tear film of patients with cystic fibrosis compared with control group. CONCLUSIONS: Apoptosis may play role in the pathogenesis of ocular changes in cystic fibrosis patients. The above results are important for the choice of the treatment of dry eye syndrome in patients with cystic fibrosis.
PURPOSE: To evaluate the concentration of sFas in tear film of cystic fibrosispatients. MATERIAL AND METHODS: Tear samples were collected from 20 patients with cystic fibrosis and 20 patients from control group. The sFas levels were determined by immunoenzymatic assay ELISA. RESULTS: We found statistically increased levels of sFas in tear film of patients with cystic fibrosis compared with control group. CONCLUSIONS: Apoptosis may play role in the pathogenesis of ocular changes in cystic fibrosispatients. The above results are important for the choice of the treatment of dry eye syndrome in patients with cystic fibrosis.