Literature DB >> 17687411

Mitochondrial dysfunction and Huntington disease.

Wei-Yan Zhang1, Zhen-Lun Gu, Zhong-Qin Liang, Zheng-Hong Qin.   

Abstract

Huntington disease (HD) is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has been identified, but the pathogenic mechanisms of the disease are still not fully understood. This paper reviews the involvement of mitochondrial dysfunction in pathogenesis of HD.

Entities:  

Year:  2006        PMID： 17687411

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  2 in total

1.  Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington's Disease.

Authors:  Weiqi Yang; Jingmo Xie; Qiang Qiang; Li Li; Xiang Lin; Yiqing Ren; Wenlei Ren; Qiong Liu; Guomin Zhou; Wenshi Wei; Hexige Saiyin; Lixiang Ma
Journal:  Neurosci Bull       Date:  2019-08-20       Impact factor: 5.203

2.  Blockage of Drp1 phosphorylation at Ser579 protects neurons against Aβ1‑42‑induced degeneration.

Authors:  Dan Xu; Ping Yang; Zhang-Jian Yang; Qiu-Gen Li; Ye-Tong Ouyang; Ting Yu; Jian-Hui Shangguan; Yu-Ying Wan; Li-Ping Jiang; Xin-Hui Qu; Xiao-Jian Han
Journal:  Mol Med Rep       Date:  2021-07-19       Impact factor: 2.952
  2 in total

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