Literature DB >> 17686639

Molecular mechanisms of COPII vesicle formation.

Marcus C S Lee1, Elizabeth A Miller.   

Abstract

The first step in protein secretion from eukaryotic cells is mediated by COPII vesicles, known for the cytoplasmic coat proteins that are the minimal machinery required to generate these small transport carriers. The five COPII coat components coordinate to create a vesicle by locally generating membrane curvature and populating the incipient bud with the appropriate cargo. This review describes the molecular details of how the COPII coat sculpts vesicles from the endoplasmic reticulum and highlights some unresolved questions regarding the regulation of this process in the complex environment of the eukaryotic cell.

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Year:  2007        PMID： 17686639     DOI： 10.1016/j.semcdb.2007.06.007

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  39 in total

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