Literature DB >> 17686629

3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1.

Shinnosuke Hosoda1, Yuichi Hashimoto.   

Abstract

We designed and synthesized novel type 1 5alpha-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5alpha-reductase inhibitor with the IC(50) value of 0.84 microM.

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Year:  2007        PMID： 17686629     DOI： 10.1016/j.bmcl.2007.07.039

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  1 in total

1.  Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents.

Authors:  Chiao-Ting Yen; Kyoko Nakagawa-Goto; Tsong-Long Hwang; Pei-Chi Wu; Susan L Morris-Natschke; Wan-Chun Lai; Kenneth F Bastow; Fang-Rong Chang; Yang-Chang Wu; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2009-12-16       Impact factor: 2.823
  1 in total

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