Asterios Triantafyllou1. 1. Oral Pathology, Department & School of Dental Studies, The University of Liverpool, Liverpool, UK. a.triantafyllou@liverpool.ac.uk
Abstract
BACKGROUND: To identify capsular components of neuromuscular spindles in man by means of immunohistochemistry. METHODS: Investigation of histologically observed neuromuscular spindles in surgical specimens with the use of markers for sheath cells and basement membranes. RESULTS: Epithelial membrane antigen and CD34 immunoreactivities were found in the outer and inner capsular layers, respectively. S-100 protein was not expressed in the capsules and there was more collagen type IV than laminin. CONCLUSIONS: Cells resembling perineurial cells and endoneurial fibroblasts, and basement membrane rich in collagen type IV comprise the capsules of neuromuscular spindles.
BACKGROUND: To identify capsular components of neuromuscular spindles in man by means of immunohistochemistry. METHODS: Investigation of histologically observed neuromuscular spindles in surgical specimens with the use of markers for sheath cells and basement membranes. RESULTS: Epithelial membrane antigen and CD34 immunoreactivities were found in the outer and inner capsular layers, respectively. S-100 protein was not expressed in the capsules and there was more collagen type IV than laminin. CONCLUSIONS: Cells resembling perineurial cells and endoneurial fibroblasts, and basement membrane rich in collagen type IV comprise the capsules of neuromuscular spindles.
Authors: Lucio Díaz-Flores; Ricardo Gutiérrez; Francisco J Sáez; Lucio Díaz-Flores; Juan F Madrid Journal: J Cell Mol Med Date: 2013-04 Impact factor: 5.310