Literature DB >> 17685621

N-heterocyclic carbene catalyzed ring expansion of 4-formyl-beta-lactams: synthesis of succinimide derivatives.

Gong-Qiang Li1, Yi Li, Li-Xin Dai, Shu-Li You.   

Abstract

N-heterocyclic carbene (NHC) has been employed as an efficient catalyst for ring expansion of 4-formyl-beta-lactams, allowing the facile synthesis of succinimide derivatives. This organocatalytic process features readily availability of the catalyst, low catalyst loading, and mild reaction conditions.

Entities:  

Year:  2007        PMID： 17685621     DOI： 10.1021/ol0713537

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Asymmetric NHC-catalyzed synthesis of α-fluoroamides from readily accessible α-fluoroenals.

Authors:  Philip Wheeler; Harit U Vora; Tomislav Rovis
Journal:  Chem Sci       Date:  2013-04       Impact factor: 9.825

2.  Exploiting Acyl and Enol Azolium Intermediates via NHeterocyclic Carbene Catalyzed Reactions of Alpha-Reducible Aldehydes.

Authors:  Harit U Vora; Philip Wheeler; Tomislav Rovis
Journal:  Adv Synth Catal       Date:  2012-04-19       Impact factor: 5.837

3.  Alpha'-hydroxyenones as mechanistic probes and scope-expanding surrogates for alpha,beta-unsaturated aldehydes in N-heterocyclic carbene-catalyzed reactions.

Authors:  Pei-Chen Chiang; Michael Rommel; Jeffrey W Bode
Journal:  J Am Chem Soc       Date:  2009-06-24       Impact factor: 15.419

4.  A reaction mode of carbene-catalysed aryl aldehyde activation and induced phenol OH functionalization.

Authors:  Xingkuan Chen; Hongling Wang; Kazuki Doitomi; Chong Yih Ooi; Pengcheng Zheng; Wangsheng Liu; Hao Guo; Song Yang; Bao-An Song; Hajime Hirao; Yonggui Robin Chi
Journal:  Nat Commun       Date:  2017-05-25       Impact factor: 14.919
  4 in total

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