| Literature DB >> 17683933 |
Dae-Seop Shin1, Jiin Kim, Dong Cho Han, Kwang-Hee Son, Chang Woo Lee, Hwan-Mook Kim, Su Hyung Hong, Byoung-Mog Kwon.
Abstract
A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.Entities:
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Year: 2007 PMID： 17683933 DOI： 10.1016/j.bmcl.2007.07.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823