Literature DB >> 17682107

Pulmonary versus systemic delivery of antibiotics: comparison of vancomycin dispositions in the isolated rat lung.

María José de Jesús Valle1, Francisco González López, Alfonso Domínguez-Gil Hurlé, Amparo Sánchez Navarro.   

Abstract

Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.

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Year:  2007        PMID： 17682107      PMCID： PMC2043261          DOI： 10.1128/AAC.00099-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Influence of flow rate on the disposition of levofloxacin and netilmicin in the isolated rat lung.

Authors:  María Santos Martínez Martínez; Clara Isabel Colino Gandarillas; José Martínez Lanao; Amparo Sánchez Navarro
Journal:  Eur J Pharm Sci       Date:  2005-01-19       Impact factor: 4.384

Review 2.  Continuous versus intermittent intravenous administration of antibiotics: a meta-analysis of randomised controlled trials.

Authors:  Sofia K Kasiakou; George J Sermaides; Argyris Michalopoulos; Elpidoforos S Soteriades; Matthew E Falagas
Journal:  Lancet Infect Dis       Date:  2005-09       Impact factor: 25.071

3.  MRSA pneumonia: better outcome through continuous infusion of vancomycin?

Authors:  Stijn Blot
Journal:  Crit Care Med       Date:  2005-09       Impact factor: 7.598

Review 4.  Antimicrobial agents for treatment of serious infections caused by resistant Staphylococcus aureus and enterococci.

Authors:  G M Eliopoulos
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2005-12       Impact factor: 3.267

5.  Aerosolized vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infection in cystic fibrosis.

Authors:  L Máiz; R Cantón; N Mir; F Baquero; H Escobar
Journal:  Pediatr Pulmonol       Date:  1998-10

6.  Aerosolized vancomycin for treatment of airway colonization by methicillin-resistant Staphylococcus aureus.

Authors:  L Weathers; D Riggs; M Santeiro; R E Weibley
Journal:  Pediatr Infect Dis J       Date:  1990-03       Impact factor: 2.129

7.  Deposition patterns of aerosolized drugs within human lungs: effects of ventilatory parameters.

Authors:  T B Martonen; I M Katz
Journal:  Pharm Res       Date:  1993-06       Impact factor: 4.200

8.  [Effect of inhaled vancomycin hydrochloride on elimination of methicillin-resistant Staphylococcus aureus].

Authors:  M Shirai; K Ide; M Sato; M Murakami; Y Tanaka; A Sato; K Chida
Journal:  Nihon Kyobu Shikkan Gakkai Zasshi       Date:  1995-11

9.  A 10-year report of patients in a prolonged respiratory care unit.

Authors:  F J Indihar
Journal:  Minn Med       Date:  1991-04

10.  Monitoring of vancomycin serum levels for the treatment of staphylococcal infections.

Authors:  M D Kitzis; F W Goldstein
Journal:  Clin Microbiol Infect       Date:  2006-01       Impact factor: 8.067
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  4 in total

1.  Antibacterial efficacy of inhalable levofloxacin-loaded polymeric nanoparticles against E. coli biofilm cells: the effect of antibiotic release profile.

Authors:  Wean Sin Cheow; Matthew Wook Chang; Kunn Hadinoto
Journal:  Pharm Res       Date:  2010-04-21       Impact factor: 4.200

2.  Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance.

Authors:  Olga B Garbuzenko; Maha Saad; Vitaly P Pozharov; Kenneth R Reuhl; Gediminas Mainelis; Tamara Minko
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-24       Impact factor: 11.205

3.  Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice.

Authors:  G Mainelis; S Seshadri; O B Garbuzenko; T Han; Z Wang; T Minko
Journal:  J Aerosol Med Pulm Drug Deliv       Date:  2013-03-26       Impact factor: 2.849

4.  Pilot Study of Aerosolised Plus Intravenous Vancomycin in Mechanically Ventilated Patients with Methicillin-Resistant Staphylococcus Aureus Pneumonia.

Authors:  Jun Yeun Cho; Hyung-Sook Kim; Hye-Joo Yang; Yeon Joo Lee; Jong Sun Park; Ho Il Yoon; Hong Bin Kim; Jae-Joon Yim; Jae-Ho Lee; Choon-Taek Lee; Young-Jae Cho
Journal:  J Clin Med       Date:  2020-02-09       Impact factor: 4.241
  4 in total

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