Literature DB >> 17681759

A synthetic entry to pladienolide B and FD-895.

Alexander L Mandel1, Brian D Jones, James J La Clair, Michael D Burkart.   

Abstract

Presented within are syntheses of the pladienolide B and FD-895 side-chains, as well as models of the essential ring-closing metathesis and Stille coupling that will be used to complete their total syntheses. Several analogs of the pladienolide B side-chain were also prepared in order to evaluate the scope of the methodology and to create a library of structures that could be used for stereochemical and SAR analyses.

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Year:  2007        PMID： 17681759      PMCID： PMC2652656          DOI： 10.1016/j.bmcl.2007.06.094

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  26 in total

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