CASE REPORT: It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. CONCLUSION: It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.
CASE REPORT: It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings. Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic cortex resulted in a reduction in seizures. CONCLUSION: It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while EEG continues to demonstrate focal findings.
Authors: Nadia Colombo; Laura Tassi; Carlo Galli; Alberto Citterio; Giorgio Lo Russo; Giuseppe Scialfa; Roberto Spreafico Journal: AJNR Am J Neuroradiol Date: 2003-04 Impact factor: 3.825
Authors: Christin M Eltze; Wui K Chong; Sanjay Bhate; Brian Harding; Brian G R Neville; J Helen Cross Journal: Epilepsia Date: 2005-12 Impact factor: 5.864
Authors: R A Bronen; K P Vives; J H Kim; R K Fulbright; S S Spencer; D D Spencer Journal: AJNR Am J Neuroradiol Date: 1997 Jun-Jul Impact factor: 3.825
Authors: R Sankar; J G Curran; J W Kevill; P J Rintahaka; D A Shewmon; H V Vinters Journal: AJNR Am J Neuroradiol Date: 1995 Jun-Jul Impact factor: 3.825