Yuji Kadoi1, Fumio Goto. 1. Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Japan.
Abstract
PURPOSE: The purpose of this study was to retrospectively examine whether sevoflurane anesthesia had any ameliorative effects on postoperative cognitive dysfunction in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS: One hundred and nine patients underwent elective CABG surgery at our institution from May 1999 to May 2001. From May 1999 to August 2000, the main anesthetic regime used included a propofol infusion with no volatile anesthetic being administered during the surgery. From September 2000 to May 2001, the main anesthetic regime used was 1.5%-2.0% sevoflurane from the postinduction period until the end of the surgery. All patients underwent a battery of neurological and neuropsychological tests 1 day before and 6 months after the operation. RESULTS: The use of sevoflurane did not have any significant effects on the postoperative levels of cognitive dysfunction. In contrast, multiple logistic analysis showed that age [odds ratio (OR), 1.3; P = 0.047], diabetes mellitus (OR, 2.5; P = 0.03), and atherosclerosis of the ascending aorta (OR, 1.4; P = 0.047) appeared to be predictive factors of postoperative cognitive dysfunction. CONCLUSION: This retrospective study showed no relationship between postoperative cognitive dysfunction and the use of sevoflurane.
PURPOSE: The purpose of this study was to retrospectively examine whether sevoflurane anesthesia had any ameliorative effects on postoperative cognitive dysfunction in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS: One hundred and nine patients underwent elective CABG surgery at our institution from May 1999 to May 2001. From May 1999 to August 2000, the main anesthetic regime used included a propofol infusion with no volatile anesthetic being administered during the surgery. From September 2000 to May 2001, the main anesthetic regime used was 1.5%-2.0% sevoflurane from the postinduction period until the end of the surgery. All patients underwent a battery of neurological and neuropsychological tests 1 day before and 6 months after the operation. RESULTS: The use of sevoflurane did not have any significant effects on the postoperative levels of cognitive dysfunction. In contrast, multiple logistic analysis showed that age [odds ratio (OR), 1.3; P = 0.047], diabetes mellitus (OR, 2.5; P = 0.03), and atherosclerosis of the ascending aorta (OR, 1.4; P = 0.047) appeared to be predictive factors of postoperative cognitive dysfunction. CONCLUSION: This retrospective study showed no relationship between postoperative cognitive dysfunction and the use of sevoflurane.
Authors: M F Newman; J L Kirchner; B Phillips-Bute; V Gaver; H Grocott; R H Jones; D B Mark; J G Reves; J A Blumenthal Journal: N Engl J Med Date: 2001-02-08 Impact factor: 91.245
Authors: G W Roach; M Kanchuger; C M Mangano; M Newman; N Nussmeier; R Wolman; A Aggarwal; K Marschall; S H Graham; C Ley Journal: N Engl J Med Date: 1996-12-19 Impact factor: 91.245
Authors: Joseph P Mathew; Hilary P Grocott; Barbara Phillips-Bute; Mark Stafford-Smith; Daniel T Laskowitz; Daniel Rossignol; James A Blumenthal; Mark F Newman Journal: Stroke Date: 2003-02 Impact factor: 7.914
Authors: Karine Julier; Rafaela da Silva; Carlos Garcia; Lukas Bestmann; Philippe Frascarolo; Andreas Zollinger; Pierre-Guy Chassot; Edith R Schmid; Marko I Turina; Ludwig K von Segesser; Thomas Pasch; Donat R Spahn; Michael Zaugg Journal: Anesthesiology Date: 2003-06 Impact factor: 7.892
Authors: Michael S Green; Parmis Green; Lee Neubert; Kirtanaa Voralu; Poovendran Saththasivam; George Mychaskiw Journal: Anesth Pain Med Date: 2015-02-01
Authors: Danielle Greaves; Peter J Psaltis; Daniel H J Davis; Tyler J Ross; Erica S Ghezzi; Amit Lampit; Ashleigh E Smith; Hannah A D Keage Journal: J Am Heart Assoc Date: 2020-11-07 Impact factor: 6.106