| Literature DB >> 17678711 |
Masanori Maeda1, Yoshiki Yanagawa, Kazuya Iwabuchi, Keita Minami, Yuji Nakamaru, Dai Takagi, Satoshi Fukuda, Kazunori Onoé.
Abstract
Interleukin (IL)-21 shows pleiotropic effects on the proliferation, differentiation, and effector functions of leukocytes. However, the influence of IL-21 on dendritic cell (DC) activation of natural killer T (NKT) cells has not yet been elucidated. In the present study, we examined the effect of IL-21 on murine myeloid DC ability to induce NKT cell production of interferon-gamma (IFN-gamma) and IL-4. Pretreatment of DCs with IL-21 and alpha-galactosylceramide (alpha-GalCer), an NKT cell-specific ligand, resulted in the enhanced ability of the DCs to induce NKT cell production of IFN-gamma but not IL-4 in vitro compared to DCs pretreated with alpha-GalCer alone. A similar effect of IL-21 was observed when DCs pretreated with IL-21 and alpha-GalCer in vitro were transferred into naïve mice. Direct administration of IL-21 to the mice also enhanced IFN-gamma production after injection of alpha-GalCer. Thus, IL-21 can modify DC ability to selectively enhance NKT cell production of IFN-gamma upon stimulation with alpha-GalCer.Entities:
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Year: 2007 PMID： 17678711 DOI： 10.1016/j.imbio.2007.03.007
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144