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Literature DB >> 17675260

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.

Brett Hall¹, Jennifer Dembinski, A Kate Sasser, Matus Studeny, Michael Andreeff, Frank Marini.

Abstract

Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumors in situ. In this review article, we describe the biological properties of MSC within the tumor microenvironment and discuss the potential use of MSC and other bone marrow-derived cell populations as delivery vehicles for antitumor proteins.

Entities: Disease

Mesh：

Year: 2007 PMID： 17675260 DOI： 10.1532/IJH97.06230

Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490

138 in total

1. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.

Authors: Yasushi Sato; Hironobu Araki; Junji Kato; Kiminori Nakamura; Yutaka Kawano; Masayoshi Kobune; Tsutomu Sato; Koji Miyanishi; Tetsuji Takayama; Minoru Takahashi; Rishu Takimoto; Satoshi Iyama; Takuya Matsunaga; Seiji Ohtani; Akihiro Matsuura; Hirofumi Hamada; Yoshiro Niitsu
Journal: Blood Date: 2005-04-07 Impact factor: 22.113

2. Tissue-specific engraftment after in utero transplantation of allogeneic mesenchymal stem cells into sheep fetuses.

Authors: Andreina Schoeberlein; Wolfgang Holzgreve; Lisbeth Dudler; Sinuhe Hahn; Daniel V Surbek
Journal: Am J Obstet Gynecol Date: 2005-04 Impact factor: 8.661

Review 3. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.

Authors: M D Sternlicht; M J Bissell; Z Werb
Journal: Oncogene Date: 2000-02-21 Impact factor: 9.867

Review 4. Adult bone marrow stem cells for cell and gene therapies: implications for greater use.

Authors: Christopher B Ballas; Steven P Zielske; Stanton L Gerson
Journal: J Cell Biochem Suppl Date: 2002

5. The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types.

Authors: Christine A Iacobuzio-Donahue; Pedram Argani; Paula M Hempen; Jessa Jones; Scott E Kern
Journal: Cancer Res Date: 2002-09-15 Impact factor: 12.701

Review 6. Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?

Authors: Kevin Harrington; Luis Alvarez-Vallina; Marka Crittenden; Michael Gough; Heung Chong; Rosa Maria Diaz; Georges Vassaux; Nicholas Lemoine; Richard Vile
Journal: Hum Gene Ther Date: 2002-07-20 Impact factor: 5.695

7. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.

Authors: Hippokratis Kiaris; Ioulia Chatzistamou; George Trimis; Matrisa Frangou-Plemmenou; Agatha Pafiti-Kondi; Anastasios Kalofoutis
Journal: Cancer Res Date: 2005-03-01 Impact factor: 12.701

8. Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.

Authors: G Richter; S Krüger-Krasagakes; G Hein; C Hüls; E Schmitt; T Diamantstein; T Blankenstein
Journal: Cancer Res Date: 1993-09-15 Impact factor: 12.701

9. Transforming growth factor-beta1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion.

Authors: Natalia Wright; Teresa Laín de Lera; Carelia García-Moruja; Rosa Lillo; Félix García-Sánchez; Antonio Caruz; Joaquin Teixidó
Journal: Blood Date: 2003-05-29 Impact factor: 22.113

10. Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice.

Authors: Valeria Roni; Walter Habeler; Anna Parenti; Stefano Indraccolo; Eleonora Gola; Valeria Tosello; Roberta Cortivo; Giovanni Abatangelo; Luigi Chieco-Bianchi; Alberto Amadori
Journal: Exp Cell Res Date: 2003-07-01 Impact factor: 3.905

81 in total

1. Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors.

Authors: Ann H Klopp; Yan Zhang; Travis Solley; Felipe Amaya-Manzanares; Frank Marini; Michael Andreeff; Bisrat Debeb; Wendy Woodward; Rosemarie Schmandt; Russell Broaddus; Karen Lu; Mikhail G Kolonin
Journal: Clin Cancer Res Date: 2011-12-13 Impact factor: 12.531

Review 2. Mesenchymal stem cells: Mechanisms of immunomodulation and homing.

Authors: Hiroshi Yagi; Alejandro Soto-Gutierrez; Biju Parekkadan; Yuko Kitagawa; Ronald G Tompkins; Naoya Kobayashi; Martin L Yarmush
Journal: Cell Transplant Date: 2010-06-03 Impact factor: 4.064

3. A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions.

Authors: Hui-Yuan Hou; Hong-Liang Liang; Yu-Sheng Wang; Zhao-Xia Zhang; Bai-Ren Wang; Yuan-Yuan Shi; Xiao Dong; Yan Cai
Journal: Mol Ther Date: 2010-07-20 Impact factor: 11.454

Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.

1. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion.

2. Tissue-specific engraftment after in utero transplantation of allogeneic mesenchymal stem cells into sheep fetuses.

Review 3. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.

Review 4. Adult bone marrow stem cells for cell and gene therapies: implications for greater use.

5. The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types.

Review 6. Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery?

7. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis.

8. Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.

9. Transforming growth factor-beta1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion.

10. Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice.

1. Omental adipose tissue-derived stromal cells promote vascularization and growth of endometrial tumors.

Review 2. Mesenchymal stem cells: Mechanisms of immunomodulation and homing.

3. A therapeutic strategy for choroidal neovascularization based on recruitment of mesenchymal stem cells to the sites of lesions.

4. An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies.

5. Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses.

Review 6. Stem cells and cell therapies in lung biology and lung diseases.

Review 7. The pharmacology of regenerative medicine.

8. Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.

Review 9. Hypoxic tumor microenvironment and cancer cell differentiation.

Review 10. Applications of neural and mesenchymal stem cells in the treatment of gliomas.