OBJECTIVE: To examine the natural history and detailed outcome of antenatally diagnosed abdominal wall defects. METHODS: This was a retrospective review of the antenatal reports, pediatric surgery records and subsequent follow-up information of all cases of omphalocele and gastroschisis diagnosed in a 10-year period in our tertiary referral center. RESULTS: There were 109 cases of abdominal wall defects, including omphalocele in 67 cases and gastroschisis in 42 cases. Of the 67 cases of omphalocele there were 26 (39%) with chromosomal abnormalities and 22 (33%) underwent termination of pregnancy, mainly for associated structural abnormalities. Of the ongoing 19 cases there were five (26%) in-utero deaths, 12 (63%) survivors and two (11%) neonatal deaths, both associated with prematurity. Excluding chromosomal abnormalities, the survival rate in isolated omphalocele was 7/16 (44%) whilst it was 5/25 (20%) in those with associated abnormalities. Gastroschisis was isolated in 40 (95%) cases. Among these 40 isolated cases there were two (5%) terminations. Of the 38 ongoing cases, there were two (5%) in-utero deaths, and 36 (95%) live births. Four of the 36 liveborn infants (11%) died in the postoperative period owing to complications of small bowel atresia. CONCLUSIONS: Although only 18% of infants with antenatally diagnosed omphalocele were alive in the neonatal period, postoperative morbidity was low. The majority (90%) of fetuses with antenatally diagnosed gastroschisis survived to delivery, but the mortality in affected newborns was 11%. Copyright 2007 ISUOG. Published by John Wiley & Sons, Ltd.
OBJECTIVE: To examine the natural history and detailed outcome of antenatally diagnosed abdominal wall defects. METHODS: This was a retrospective review of the antenatal reports, pediatric surgery records and subsequent follow-up information of all cases of omphalocele and gastroschisis diagnosed in a 10-year period in our tertiary referral center. RESULTS: There were 109 cases of abdominal wall defects, including omphalocele in 67 cases and gastroschisis in 42 cases. Of the 67 cases of omphalocele there were 26 (39%) with chromosomal abnormalities and 22 (33%) underwent termination of pregnancy, mainly for associated structural abnormalities. Of the ongoing 19 cases there were five (26%) in-utero deaths, 12 (63%) survivors and two (11%) neonatal deaths, both associated with prematurity. Excluding chromosomal abnormalities, the survival rate in isolated omphalocele was 7/16 (44%) whilst it was 5/25 (20%) in those with associated abnormalities. Gastroschisis was isolated in 40 (95%) cases. Among these 40 isolated cases there were two (5%) terminations. Of the 38 ongoing cases, there were two (5%) in-utero deaths, and 36 (95%) live births. Four of the 36 liveborn infants (11%) died in the postoperative period owing to complications of small bowel atresia. CONCLUSIONS: Although only 18% of infants with antenatally diagnosed omphalocele were alive in the neonatal period, postoperative morbidity was low. The majority (90%) of fetuses with antenatally diagnosed gastroschisis survived to delivery, but the mortality in affected newborns was 11%. Copyright 2007 ISUOG. Published by John Wiley & Sons, Ltd.
Authors: B A Khalil; J C Gillham; L Foresythe; R Harding; T Johnston; C Wright; A Morabito Journal: Ann R Coll Surg Engl Date: 2010-06-07 Impact factor: 1.891
Authors: Anthony S de Buys Roessingh; Amélie Damphousse; Pierluigi Ballabeni; Josée Dubois; Sarah Bouchard Journal: World J Gastrointest Pathophysiol Date: 2015-11-15
Authors: Dominique Heinke; Eirini Nestoridi; Sonia Hernandez-Diaz; Paige L Williams; Janet W Rich-Edwards; Angela E Lin; Carla M Van Bennekom; Allen A Mitchell; Wendy N Nembhard; Ruth C Fretts; Drucilla J Roberts; C Wes Duke; Suzan L Carmichael; Mahsa M Yazdy Journal: Obstet Gynecol Date: 2020-01 Impact factor: 7.623
Authors: Wendy N Nembhard; Jorieke E H Bergman; Maria D Politis; Jazmín Arteaga-Vázquez; Eva Bermejo-Sánchez; Mark A Canfield; Janet D Cragan; Saeed Dastgiri; Hermien E K de Walle; Marcia L Feldkamp; Amy Nance; Miriam Gatt; Boris Groisman; Paula Hurtado-Villa; Kärin Kallén; Danielle Landau; Nathalie Lelong; Jorge Lopez-Camelo; Laura Martinez; Margery Morgan; Anna Pierini; Anke Rissmann; Antonin Šípek; Elena Szabova; Giovanna Tagliabue; Wladimir Wertelecki; Ignacio Zarante; Marian K Bakker; Vijaya Kancherla; Pierpaolo Mastroiacovo Journal: Birth Defects Res Date: 2020-10-17 Impact factor: 2.661
Authors: Russell S Kirby; Jennifer Marshall; Jean Paul Tanner; Jason L Salemi; Marcia L Feldkamp; Lisa Marengo; Robert E Meyer; Charlotte M Druschel; Russel Rickard; James E Kucik Journal: Obstet Gynecol Date: 2013-08 Impact factor: 7.623