| Literature DB >> 17673289 |
Christoph Renné1, Sarah Minner, Ralf Küppers, Martin-Leo Hansmann, Andreas Bräuninger.
Abstract
Hodgkin-Reed/Sternberg cells, the tumor cells of Hodgkin lymphoma, aberrantly express several receptor tyrosine kinases, among them TRKA whose stimulation supports B cell survival. We show here high expression of TRKA in Hodgkin-Reed/Sternberg cell lines as compared to normal B cells and other B cell lymphomas, without major increases in TRKA gene dosage. A fraction of TRKA is constitutively activated, likely due to the coexpression of NGFbeta, the TRKA high affinity ligand. The TRK inhibitor K-252a decreased survival of Hodgkin-Reed/Sternberg cell lines accompanied by decreased AKT activation. Inclusion of TRK inhibitors in therapeutic regimens may thus be an interesting possibility.Entities:
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Year: 2007 PMID： 17673289 DOI： 10.1016/j.leukres.2007.05.019
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156