BACKGROUND: Patients with inflammatory rheumatic diseases have an increased risk of developing atherosclerosis. However, the question of whether patients with familial Mediterranean fever (FMF) are at risk of atherosclerosis and related diseases remains controversial. OBJECTIVE: We aimed to use transthoracic Doppler echocardiography to investigate coronary flow reserve (CFR) and left ventricular (LV) diastolic function in patients with FMF. METHODS: CFR and LV diastolic function were studied in 33 patients with FMF (16 men, 17 women; mean age, 36.7+/-12.0 years) and 35 healthy volunteers (20 men, 15 women; mean age, 36.8+/-5.2 years). Coronary diastolic peak flow velocities (DPFV) were measured at baseline and after dipyridamole infusion. LV diastolic function was assessed by standard and tissue Doppler imaging. RESULTS: CFR was significantly lower in the FMF group than in the control group (2.27+/-0.38 versus 3.02+/-0.50, P<0.0001). Significant between-group differences were found regarding LV diastolic function mitral E/A ratio, mitral E-wave deceleration time, and lateral A(m). Serum high sensitivity C-reactive protein (hsCRP) levels were significantly higher in the patients with FMF, and hsCRP values independently correlated with CFR. CONCLUSIONS: Coronary microvascular function and LV diastolic function are impaired in patients with FMF. The severity of these impairments is correlated with hsCRP. Impaired CFR may be an early manifestation of cardiac involvement in patients with FMF.
BACKGROUND:Patients with inflammatory rheumatic diseases have an increased risk of developing atherosclerosis. However, the question of whether patients with familial Mediterranean fever (FMF) are at risk of atherosclerosis and related diseases remains controversial. OBJECTIVE: We aimed to use transthoracic Doppler echocardiography to investigate coronary flow reserve (CFR) and left ventricular (LV) diastolic function in patients with FMF. METHODS: CFR and LV diastolic function were studied in 33 patients with FMF (16 men, 17 women; mean age, 36.7+/-12.0 years) and 35 healthy volunteers (20 men, 15 women; mean age, 36.8+/-5.2 years). Coronary diastolic peak flow velocities (DPFV) were measured at baseline and after dipyridamole infusion. LV diastolic function was assessed by standard and tissue Doppler imaging. RESULTS: CFR was significantly lower in the FMF group than in the control group (2.27+/-0.38 versus 3.02+/-0.50, P<0.0001). Significant between-group differences were found regarding LV diastolic function mitral E/A ratio, mitral E-wave deceleration time, and lateral A(m). Serum high sensitivity C-reactive protein (hsCRP) levels were significantly higher in the patients with FMF, and hsCRP values independently correlated with CFR. CONCLUSIONS: Coronary microvascular function and LV diastolic function are impaired in patients with FMF. The severity of these impairments is correlated with hsCRP. Impaired CFR may be an early manifestation of cardiac involvement in patients with FMF.
Authors: Muhammet Murat Celik; Eyup Buyukkaya; Nilgul Ustun; Alper Bugra Nacar; Mustafa Kurt; Mehmet Fatih Karakas; Perihan Bilen; Mehmet Duru; Nihat Sen; Adnan Burak Akcay Journal: Wien Klin Wochenschr Date: 2015-03-19 Impact factor: 1.704
Authors: György Kerekes; Pál Soltész; Michael T Nurmohamed; Miguel A Gonzalez-Gay; Maurizio Turiel; Edit Végh; Yehuda Shoenfeld; Iain McInnes; Zoltán Szekanecz Journal: Nat Rev Rheumatol Date: 2012-02-21 Impact factor: 20.543
Authors: Idris Ardic; Mehmet Gungor Kaya; Mikail Yarlioglues; Orhan Dogdu; Mehmet Celikbilek; Mahmut Akpek; Lutfi Akyol; Edip Torun Journal: Rheumatol Int Date: 2010-07-22 Impact factor: 2.631