Literature DB >> 176727

Blockade of prolactin action by an antiserum to its receptors.

R P Shiu, H G Friesen.   

Abstract

A guinea pig antiserum to prolactin receptors selectively inhibited the binding of [125I] prolactin to its membrane receptors as well as prolactin-mediated incorporation of [3H] leucine into casein and transport of [14C] aminoisobutyric acid, but was without effect on the binding of [125I] insulin and insulin-mediated events in explants of rabbit mammary glands maintained in culture. These findings provide direct evidence for an obligatory functional role of a membrane receptor in mediating the action of a polypeptide hormone.

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Year:  1976        PMID： 176727     DOI： 10.1126/science.176727

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action.

Authors:  C R Kahn; K Baird; J S Filier; D B Jarrett
Journal:  J Clin Invest       Date:  1977-11       Impact factor: 14.808

2.  Biomolecular information analysis in neurotransmitter systems.

Authors:  S C Brooks
Journal:  Acta Biotheor       Date:  1984       Impact factor: 1.774

3.  Lactogenic response of mouse mammary explants from different days of pregnancy to placental lactogen and pituitary prolactin.

Authors:  J Ways; E Markoff; L Ogren; F Talamantes
Journal:  In Vitro       Date:  1979-11

4.  Interaction of cell-membrane prolactin receptor with its antibody.

Authors:  R P Shiu; H G Friesen
Journal:  Biochem J       Date:  1976-09-01       Impact factor: 3.857

5.  Prolactin-like activity of anti-prolactin receptor antibodies on casein and DNA synthesis in the mammary gland.

Authors:  J Djiane; L M Houdebine; P A Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

6.  Evolution of studies on antireceptor antibodies and disease.

Authors:  P R Carnegie; I R Mackay
Journal:  Springer Semin Immunopathol       Date:  1982

7.  Autoantibodies to hormone receptors.

Authors:  L C Harrison
Journal:  Springer Semin Immunopathol       Date:  1982

8.  Hormonal regulation of casein messenger RNA (mRNA).

Authors:  M R Banerjee; P M Terry; S Sakai; F K Lin; R Ganguly
Journal:  In Vitro       Date:  1978-01

9.  Determination and properties of proteohormone receptors in malignant gynecological tumors with special reference to lactogen receptors in human breast cancer.

Authors:  H G Bohnet
Journal:  Arch Gynecol       Date:  1980

10.  Characterization of prolactin receptors in pig mammary gland.

Authors:  S Sakai; M Katoh; P Berthon; P A Kelly
Journal:  Biochem J       Date:  1984-12-15       Impact factor: 3.857
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