Literature DB >> 17671635

The legacy of the Philadelphia chromosome.

Gary A Koretzky1.   

Abstract

The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered. This Review series includes contributions from individuals who performed critical experiments addressing some of the most important of these questions, reflecting the nearly 50 years of work inspired by Nowell's initial finding. The legacy of the Philadelphia chromosome now serves as a paradigm for how basic science discoveries can lead to effective new approaches for the treatment of human disease.

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Year:  2007        PMID： 17671635      PMCID： PMC1934583          DOI： 10.1172/JCI33032

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  38 in total

Review 1.  Stem cells in prostate cancer initiation and progression.

Authors:  Devon A Lawson; Owen N Witte
Journal:  J Clin Invest       Date:  2007-08       Impact factor: 14.808

2.  Identification of a transformation-specific antigen induced by an avian sarcoma virus.

Authors:  J S Brugge; R L Erikson
Journal:  Nature       Date:  1977-09-22       Impact factor: 49.962

3.  Protein kinase activity associated with the avian sarcoma virus src gene product.

Authors:  M S Collett; R L Erikson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  Fused transcript of abl and bcr genes in chronic myelogenous leukaemia.

Authors:  E Shtivelman; B Lifshitz; R P Gale; E Canaani
Journal:  Nature       Date:  1985 Jun 13-19       Impact factor: 49.962

5.  Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.

Authors:  J D Rowley
Journal:  Nature       Date:  1973-06-01       Impact factor: 49.962

6.  Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.

Authors:  Charles L Sawyers; Andreas Hochhaus; Eric Feldman; John M Goldman; Carole B Miller; Oliver G Ottmann; Charles A Schiffer; Moshe Talpaz; Francois Guilhot; Michael W N Deininger; Thomas Fischer; Steve G O'Brien; Richard M Stone; Carlo B Gambacorti-Passerini; Nigel H Russell; Jose J Reiffers; Thomas C Shea; Bernard Chapuis; Steven Coutre; Sante Tura; Enrica Morra; Richard A Larson; Alan Saven; Christian Peschel; Alois Gratwohl; Franco Mandelli; Monique Ben-Am; Insa Gathmann; Renaud Capdeville; Ronald L Paquette; Brian J Druker
Journal:  Blood       Date:  2002-05-15       Impact factor: 22.113

7.  Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

Authors:  B J Druker; M Talpaz; D J Resta; B Peng; E Buchdunger; J M Ford; N B Lydon; H Kantarjian; R Capdeville; S Ohno-Jones; C L Sawyers
Journal:  N Engl J Med       Date:  2001-04-05       Impact factor: 91.245

8.  Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.

Authors:  K Stam; N Heisterkamp; G Grosveld; A de Klein; R S Verma; M Coleman; H Dosik; J Groffen
Journal:  N Engl J Med       Date:  1985-12-05       Impact factor: 91.245

9.  Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen.

Authors:  J A Drebin; V C Link; R A Weinberg; M I Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

10.  An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

Authors:  J B Konopka; S M Watanabe; O N Witte
Journal:  Cell       Date:  1984-07       Impact factor: 41.582
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  18 in total

1.  Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells.

Authors:  Angela Proctor; Imola G Zigoneanu; Qunzhao Wang; Christopher E Sims; David S Lawrence; Nancy L Allbritton
Journal:  Analyst       Date:  2016-10-17       Impact factor: 4.616

Review 2.  New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics.

Authors:  Thomas R Hawn; Javeed A Shah; Daniel Kalman
Journal:  Immunol Rev       Date:  2015-03       Impact factor: 12.988

3.  Double Philadelphia Chromosomes- A Rare, Yet an Important Cytogenetic Phenomenon of Prognostic Significance in De Novo Acute Lymphoblastic Leukemia.

Authors:  Shanthala Siddappa; Syed Adil Hassan; Kavitha B Lingappa; L K Rajeev; M Padma; Lokanatha Dasappa
Journal:  Indian J Hematol Blood Transfus       Date:  2022-04-16       Impact factor: 0.915

4.  Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma.

Authors:  Sarasija Naini; Katherine T Etheridge; Stacey J Adam; Stephen J Qualman; Rex C Bentley; Christopher M Counter; Corinne M Linardic
Journal:  Cancer Res       Date:  2008-12-01       Impact factor: 12.701

Review 5.  The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies.

Authors:  Meng Michelle Xu; Yang Pu; Yuan Zhang; Yang-Xin Fu
Journal:  Trends Immunol       Date:  2016-01-07       Impact factor: 16.687

Review 6.  The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium.

Authors:  Bastihalli T Diwakar; Arvind M Korwar; Robert F Paulson; K Sandeep Prabhu
Journal:  Adv Cancer Res       Date:  2017-08-31       Impact factor: 6.242

Review 7.  NUAK2: an emerging acral melanoma oncogene.

Authors:  Takeshi Namiki; Sergio G Coelho; Vincent J Hearing
Journal:  Oncotarget       Date:  2011-09

8.  Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.

Authors:  Ruth J Napier; Brian A Norris; Alyson Swimm; Cynthia R Giver; Wayne A C Harris; Julie Laval; Brooke A Napier; Gopi Patel; Ryan Crump; Zhenghong Peng; William Bornmann; Bali Pulendran; R Mark Buller; David S Weiss; Rabindra Tirouvanziam; Edmund K Waller; Daniel Kalman
Journal:  PLoS Pathog       Date:  2015-03-30       Impact factor: 6.823

Review 9.  Genetics of autosomal mosaic chromosomal alteration (mCA).

Authors:  Xiaoxi Liu; Yoichiro Kamatani; Chikashi Terao
Journal:  J Hum Genet       Date:  2021-07-28       Impact factor: 3.172

Review 10.  DNA sequencing methods in human genetics and disease research.

Authors:  Hans Lehrach
Journal:  F1000Prime Rep       Date:  2013-09-02
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