Literature DB >> 17671360

A structural insight into lead neurotoxicity and calmodulin activation by heavy metals.

Petri Kursula1, Viivi Majava.   

Abstract

Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.

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Year:  2007        PMID： 17671360      PMCID： PMC2335165          DOI： 10.1107/S1744309107034525

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  26 in total

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Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1997-05-01

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Authors:  M Kern; M Wisniewski; L Cabell; G Audesirk
Journal:  Neurotoxicology       Date:  2000-06       Impact factor: 4.294

5.  Metal ion selectivity for formation of the calmodulin-metal-target peptide ternary complex studied by surface plasmon resonance spectroscopy.

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Journal:  Biochim Biophys Acta       Date:  1999-10-12

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Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2003-09-19

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Journal:  Biometals       Date:  1998-09       Impact factor: 2.949

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Authors:  P L Goering
Journal:  Neurotoxicology       Date:  1993 Summer-Fall       Impact factor: 4.294

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Journal:  Biochem Pharmacol       Date:  1986-04-15       Impact factor: 5.858

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Journal:  Environ Health Perspect       Date:  1990-11       Impact factor: 9.031
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  19 in total

Review 1.  Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.

Authors:  Rakshya Gorkhali; Kenneth Huang; Michael Kirberger; Jenny J Yang
Journal:  Metallomics       Date:  2016-06-01       Impact factor: 4.526

2.  High affinity interactions of Pb2+ with synaptotagmin I.

Authors:  Sachin Katti; Bin Her; Atul K Srivastava; Alexander B Taylor; Steve W Lockless; Tatyana I Igumenova
Journal:  Metallomics       Date:  2018-09-19       Impact factor: 4.526

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Journal:  Toxicol Res (Camb)       Date:  2015-11-25       Impact factor: 3.524

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Journal:  J Am Chem Soc       Date:  2011-06-17       Impact factor: 15.419

Review 5.  Lead poisoning: acute exposure of the heart to lead ions promotes changes in cardiac function and Cav1.2 ion channels.

Authors:  Gonzalo Ferreira de Mattos; Carlos Costa; Florencia Savio; M Alonso; G L Nicolson
Journal:  Biophys Rev       Date:  2017-08-23

6.  Atomic force microscopy study of the conformational change in immobilized calmodulin.

Authors:  Sanja Trajkovic; Xiaoning Zhang; Sylvia Daunert; Yuguang Cai
Journal:  Langmuir       Date:  2011-07-27       Impact factor: 3.882

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Authors:  Henni Piirainen; Maarit Hellman; Helena Tossavainen; Perttu Permi; Petri Kursula; Veli-Pekka Jaakola
Journal:  Biophys J       Date:  2015-02-17       Impact factor: 4.033

8.  Contrast-matched small-angle X-ray scattering from a heavy-atom-labeled protein in structure determination: application to a lead-substituted calmodulin-peptide complex.

Authors:  Alexander Grishaev; Nicholas J Anthis; G Marius Clore
Journal:  J Am Chem Soc       Date:  2012-08-29       Impact factor: 15.419

9.  Metal toxicity and opportunistic binding of Pb(2+) in proteins.

Authors:  Michael Kirberger; Hing C Wong; Jie Jiang; Jenny J Yang
Journal:  J Inorg Biochem       Date:  2013-04-19       Impact factor: 4.155

10.  Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation.

Authors:  Frank J Smith; Victor P T Pau; Gino Cingolani; Brad S Rothberg
Journal:  Structure       Date:  2012-10-18       Impact factor: 5.006
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