PURPOSE: To identify reliable predictors of chemoradiation resistance of advanced head and neck squamous cell carcinoma (HNSCC). EXPERIMENTAL DESIGN: We did a matched-pair analysis of 20 chemoradiation-resistant and 20 sensitive HNSCCs, identified among a series of 104 consecutively treated cases. We compared the global DNA copy number profiles derived from comparative genomic hybridization analysis of both groups to identify genetic markers associated with chemoradiation resistance. RESULTS: Although sensitive and resistant case groups were characterized by a similar total number of genetic aberrations, high-level amplifications were more frequent in resistant tumors. Resistant tumors were characterized by a different profile of genetic changes. Gains of 3q11-q13, 3q21-q26.1, and 6q22-q27 and losses of 3p11-pter and 4p11-pter were significantly associated with chemoradiation resistance. High-level amplifications unique to resistant cases involved the chromosomal regions 1p32, 3q24, 7p11.1, 7p11.2-12, 8p11.1, 8p11.1-12, 12q15, 13q21, 15q12, 18p11.3, and 18q11. CONCLUSIONS: Sensitive and resistant HNSCCs are characterized by divergent genomic profiles. These profiles may be valuable as predictive markers of treatment failure.
PURPOSE: To identify reliable predictors of chemoradiation resistance of advanced head and neck squamous cell carcinoma (HNSCC). EXPERIMENTAL DESIGN: We did a matched-pair analysis of 20 chemoradiation-resistant and 20 sensitive HNSCCs, identified among a series of 104 consecutively treated cases. We compared the global DNA copy number profiles derived from comparative genomic hybridization analysis of both groups to identify genetic markers associated with chemoradiation resistance. RESULTS: Although sensitive and resistant case groups were characterized by a similar total number of genetic aberrations, high-level amplifications were more frequent in resistant tumors. Resistant tumors were characterized by a different profile of genetic changes. Gains of 3q11-q13, 3q21-q26.1, and 6q22-q27 and losses of 3p11-pter and 4p11-pter were significantly associated with chemoradiation resistance. High-level amplifications unique to resistant cases involved the chromosomal regions 1p32, 3q24, 7p11.1, 7p11.2-12, 8p11.1, 8p11.1-12, 12q15, 13q21, 15q12, 18p11.3, and 18q11. CONCLUSIONS: Sensitive and resistant HNSCCs are characterized by divergent genomic profiles. These profiles may be valuable as predictive markers of treatment failure.
Authors: Ilda P Ribeiro; Francisco Marques; Leonor Barroso; Jorge Miguéis; Francisco Caramelo; André Santos; Maria J Julião; Joana B Melo; Isabel M Carreira Journal: Mol Cytogenet Date: 2017-04-11 Impact factor: 2.009
Authors: Christian Gluck; Alexandra Glathar; Maria Tsompana; Norma Nowak; Lee Ann Garrett-Sinha; Michael J Buck; Satrajit Sinha Journal: PLoS Genet Date: 2019-07-15 Impact factor: 5.917
Authors: Malin Lando; Marit Holden; Linn C Bergersen; Debbie H Svendsrud; Trond Stokke; Kolbein Sundfør; Ingrid K Glad; Gunnar B Kristensen; Heidi Lyng Journal: PLoS Genet Date: 2009-11-13 Impact factor: 5.917
Authors: Ilda P Ribeiro; Francisco Marques; Leonor Barroso; Joana Rodrigues; Francisco Caramelo; Joana B Melo; Isabel M Carreira Journal: Mol Med Rep Date: 2017-09-05 Impact factor: 2.952