Literature DB >> 17669562

Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation.

Carlota Dobaño1, Georg Widera, Dietmar Rabussay, Denise L Doolan.   

Abstract

We evaluated the effectiveness of in vivo electroporation (EP) for the enhancement of immune responses induced by DNA plasmids encoding the pre-erythrocytic Plasmodium yoelii antigens PyCSP and PyHEP17 administered intramuscularly and intradermally to mice. EP resulted in a 16- and 2-fold enhancement of antibody responses to PyCSP and PyHEP17, respectively. Immunization with 5 microg of DNA via EP was equivalent to 50 microg of DNA via conventional needle, thus reducing by 10-fold the required dose to produce a given effect. Moreover, IFN-gamma responses were increased by approximately 2-fold. Data demonstrate the potential of EP to enhance immune responses to DNA vaccines against infectious agents.

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Year:  2007        PMID： 17669562     DOI： 10.1016/j.vaccine.2007.06.036

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  16 in total

1.  Markedly enhanced immunogenicity of a Pfs25 DNA-based malaria transmission-blocking vaccine by in vivo electroporation.

Authors:  Ralph LeBlanc; Yessika Vasquez; Drew Hannaman; Nirbhay Kumar
Journal:  Vaccine       Date:  2007-11-20       Impact factor: 3.641

2.  Recruitment of antigen-presenting cells to the site of inoculation and augmentation of human immunodeficiency virus type 1 DNA vaccine immunogenicity by in vivo electroporation.

Authors:  Jinyan Liu; Rune Kjeken; Iacob Mathiesen; Dan H Barouch
Journal:  J Virol       Date:  2008-03-19       Impact factor: 5.103

3.  Malaria DNA vaccine gp96NTD-CSP elicits both CSP-specific antibody and CD8(+) T cell response.

Authors:  Zhangping Tan; TaoLi Zhou; Hong Zheng; Yan Ding; Wenyue Xu
Journal:  Parasitol Res       Date:  2015-03-20       Impact factor: 2.289

Review 4.  Electroporation delivery of DNA vaccines: prospects for success.

Authors:  Niranjan Y Sardesai; David B Weiner
Journal:  Curr Opin Immunol       Date:  2011-04-27       Impact factor: 7.486

Review 5.  DNA vaccines: ready for prime time?

Authors:  Michele A Kutzler; David B Weiner
Journal:  Nat Rev Genet       Date:  2008-10       Impact factor: 53.242

Review 6.  The march toward malaria vaccines.

Authors:  Stephen L Hoffman; Johan Vekemans; Thomas L Richie; Patrick E Duffy
Journal:  Vaccine       Date:  2015-08-29       Impact factor: 3.641

Review 7.  The March Toward Malaria Vaccines.

Authors:  Stephen L Hoffman; Johan Vekemans; Thomas L Richie; Patrick E Duffy
Journal:  Am J Prev Med       Date:  2015-12       Impact factor: 5.043

8.  DNA vaccination by electroporation and boosting with recombinant proteins enhances the efficacy of DNA vaccines for Schistosomiasis japonica.

Authors:  Yang Dai; Yinchang Zhu; Donald A Harn; Xiaoting Wang; Jianxia Tang; Song Zhao; Fei Lu; Xiaohong Guan
Journal:  Clin Vaccine Immunol       Date:  2009-10-07

9.  The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods.

Authors:  Shixia Wang; Chunghua Zhang; Lu Zhang; Jun Li; Zuhu Huang; Shan Lu
Journal:  Vaccine       Date:  2008-03-06       Impact factor: 3.641

10.  Optimization of electroporation-enhanced intradermal delivery of DNA vaccine using a minimally invasive surface device.

Authors:  Feng Lin; Xuefei Shen; Gleb Kichaev; Janess M Mendoza; Maria Yang; Philip Armendi; Jian Yan; Gary P Kobinger; Alexander Bello; Amir S Khan; Kate E Broderick; Niranjan Y Sardesai
Journal:  Hum Gene Ther Methods       Date:  2012-07-13       Impact factor: 2.396
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