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Literature DB >> 1766866

The ste4+ gene, essential for sexual differentiation of Schizosaccharomyces pombe, encodes a protein with a leucine zipper motif.

N Okazaki¹, K Okazaki, K Tanaka, H Okayama.

Abstract

Ste4- mutants of Schizosaccharomyces pombe are unable to undergo both mating and meiosis. We have cloned the ste4+ gene and its cDNA. The gene encodes a 264 amino acid protein with a typical leucine zipper motif homologous with the jun family. However, unlike the jun family, this protein does not have a typical basic region that precedes the leucine zipper. The transcription of this gene absolutely depends on the ste11+ gene and increases several fold upon nitrogen starvation, a general signal for sexual differentiation. Whereas ste4+ is essential for mating and meiosis, its overexpression inhibits these processes.

Entities: Chemical Species

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Year: 1991 PMID： 1766866 PMCID： PMC332508 DOI： 10.1093/nar/19.25.7043

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

25 in total

1. Sterile UGA nonsense mutants of fission yeast.

Authors: U Leupold; M Sipiczki
Journal: Curr Genet Date: 1991-07 Impact factor: 3.886

2. Pheromone production and response in sterile mutants of fission yeast.

Authors: U Leupold; M Sipiczki; R Egel
Journal: Curr Genet Date: 1991-07 Impact factor: 3.886

3. Premeiotic DNA synthesis in fission yeast.

Authors: R Egel; M Egel-Mitani
Journal: Exp Cell Res Date: 1974-09 Impact factor: 3.905

Review 4. Sexual differentiation in fission yeast.

Authors: R Egel; O Nielsen; D Weilguny
Journal: Trends Genet Date: 1990-11 Impact factor: 11.639

5. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.

Authors: S Moreno; A Klar; P Nurse
Journal: Methods Enzymol Date: 1991 Impact factor: 1.600

6. High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe.

Authors: K Okazaki; N Okazaki; K Kume; S Jinno; K Tanaka; H Okayama
Journal: Nucleic Acids Res Date: 1990-11-25 Impact factor: 16.971

7. Wee1(+)-like gene in human cells.

Authors: M Igarashi; A Nagata; S Jinno; K Suto; H Okayama
Journal: Nature Date: 1991-09-05 Impact factor: 49.962

8. Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

Authors: T Toda; M Shimanuki; M Yanagida
Journal: Genes Dev Date: 1991-01 Impact factor: 11.361

9. Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways.

Authors: T Obara; M Nakafuku; M Yamamoto; Y Kaziro
Journal: Proc Natl Acad Sci U S A Date: 1991-07-01 Impact factor: 11.205

10. Involvement of ras in sexual differentiation but not in growth control in fission yeast.

Authors: S A Nadin-Davis; A Nasim; D Beach
Journal: EMBO J Date: 1986-11 Impact factor: 11.598

18 in total

1. New nucleotide sequence data on the EMBL File Server.

Authors:
Journal: Nucleic Acids Res Date: 1992-03-25 Impact factor: 16.971

2. The 14-3-3 proteins Rad24 and Rad25 negatively regulate Byr2 by affecting its localization in Schizosaccharomyces pombe.

Authors: Fumiyo Ozoe; Rumi Kurokawa; Yasuyo Kobayashi; Hee Tae Jeong; Katsunori Tanaka; Kikuo Sen; Tsuyoshi Nakagawa; Hideyuki Matsuda; Makoto Kawamukai
Journal: Mol Cell Biol Date: 2002-10 Impact factor: 4.272

Review 10. The role of adaptor protein Ste50-dependent regulation of the MAPKKK Ste11 in multiple signalling pathways of yeast.

Authors: Massoud Ramezani-Rad
Journal: Curr Genet Date: 2003-03-11 Impact factor: 3.886

The ste4+ gene, essential for sexual differentiation of Schizosaccharomyces pombe, encodes a protein with a leucine zipper motif.

1. Sterile UGA nonsense mutants of fission yeast.

2. Pheromone production and response in sterile mutants of fission yeast.

3. Premeiotic DNA synthesis in fission yeast.

Review 4. Sexual differentiation in fission yeast.

5. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.

6. High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe.

7. Wee1(+)-like gene in human cells.

8. Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

9. Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways.

10. Involvement of ras in sexual differentiation but not in growth control in fission yeast.

1. New nucleotide sequence data on the EMBL File Server.

2. The 14-3-3 proteins Rad24 and Rad25 negatively regulate Byr2 by affecting its localization in Schizosaccharomyces pombe.

3. Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.

4. Isolation of a mammalian homologue of a fission yeast differentiation regulator.

5. Multiple upstream signals converge on the adaptor protein Mst50 in Magnaporthe grisea.

6. Compilation of sequence-specific DNA-binding proteins implicated in transcriptional control in fungi.

7. Two novel genes involved in the sexual development of Schizosaccharomyces pombe.

8. SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins.

9. Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.

Review 10. The role of adaptor protein Ste50-dependent regulation of the MAPKKK Ste11 in multiple signalling pathways of yeast.