BACKGROUND: The purpose of this study was to examine whether use of small intestinal submucosa in microsurgical urethroplasty in Wistar rats represents an alternative. METHODS: In 20 Wistar rats microsurgical urethroplasty with small intestinal submucosa was done to repair distal or proximal urethral defects. Four weeks later urethral calibration and urethrography were performed in addition to histological studies. RESULTS AND CONCLUSIONS: Of the 20 animals, 19 survived the observation period without evidence of fistulas, strictures, stenoses, or necroses. The histological results confirmed an intact tissue layer.
BACKGROUND: The purpose of this study was to examine whether use of small intestinal submucosa in microsurgical urethroplasty in Wistar rats represents an alternative. METHODS: In 20 Wistar rats microsurgical urethroplasty with small intestinal submucosa was done to repair distal or proximal urethral defects. Four weeks later urethral calibration and urethrography were performed in addition to histological studies. RESULTS AND CONCLUSIONS: Of the 20 animals, 19 survived the observation period without evidence of fistulas, strictures, stenoses, or necroses. The histological results confirmed an intact tissue layer.
Authors: A J Allman; T B McPherson; S F Badylak; L C Merrill; B Kallakury; C Sheehan; R H Raeder; D W Metzger Journal: Transplantation Date: 2001-06-15 Impact factor: 4.939
Authors: Bradley P Kropp; Earl Y Cheng; John C Pope; John W Brock; Martin A Koyle; Peter D Furness; Noel D Weigel; Rick W Keck; Kenneth A Kropp Journal: J Urol Date: 2002-10 Impact factor: 7.450