Hala Mahfouz Badran1, Magdi Elsayed Mahfouz. 1. Cardiology Department, Faculty of Medicine, Menoufiya University, Shebin El-Koom, Egypt. halamahfouz_1000@yahoo.com
Abstract
BACKGROUND: Helicobacter pyloriCagA strains could increase the risk for atrial fibrillation in patients with coronary artery disease METHODS: Serological status for H. pyloriCagA using enzyme-linked immunosorbent assay, C-reactive protein, total leucocytic count and atrial size were determined in 185 coronary artery disease patients (with and without atrial fibrillation) and 80 healthy subjects (control). RESULTS: CagA strain showed a higher prevalence in the atrial fibrillation group. Atrial dimension and C-reactive protein (independent predictors of atrial fibrillation) were significantly increased in the CagA seropositive subgroup CONCLUSIONS: There is a strong liaison between H. pylori CagA infection and atrial fibrillation in coronary artery disease. Increased C reactive protein and atrial size in atrial fibrillation patients may reflect atrial inflammatory remodeling.
BACKGROUND: Helicobacter pyloriCagA strains could increase the risk for atrial fibrillation in patients with coronary artery disease METHODS: Serological status for H. pyloriCagA using enzyme-linked immunosorbent assay, C-reactive protein, total leucocytic count and atrial size were determined in 185 coronary artery diseasepatients (with and without atrial fibrillation) and 80 healthy subjects (control). RESULTS: CagA strain showed a higher prevalence in the atrial fibrillation group. Atrial dimension and C-reactive protein (independent predictors of atrial fibrillation) were significantly increased in the CagA seropositive subgroup CONCLUSIONS: There is a strong liaison between H. pylori CagA infection and atrial fibrillation in coronary artery disease. Increased C reactive protein and atrial size in atrial fibrillationpatients may reflect atrial inflammatory remodeling.
Authors: Francesco Franceschi; Donatella Brisinda; Francesco Buccelletti; Maria Pia Ruggieri; Antonio Gasbarrini; Annarita Sorbo; Davide Marsiliani; Angela Venuti; Peter Fenici; Giovanni Gasbarrini; Nicolò Gentiloni Silveri; Riccardo Fenici Journal: Intern Emerg Med Date: 2011-05-12 Impact factor: 3.397