Literature DB >> 1766678

Expression of the ret proto-oncogene in human neuroblastoma cell lines and its increase during neuronal differentiation induced by retinoic acid.

T Tahira1, Y Ishizaka, F Itoh, M Nakayasu, T Sugimura, M Nagao.   

Abstract

Previously we observed specific expression of the ret proto-oncogene (proto-ret) in human neuroblastoma cell lines. A neuronal subline and non-neuronal sublines were isolated from the SK-N-SH cell line, which is composed of a heterogeneous cell population. Expression of proto-ret was detected in the neuronal subline, named SH-4305, but not in three non-neuronal sublines. Expression of proto-ret in the SH-4305 cells increased markedly after treatment with retinoic acid for 1 day, with concomitant morphological change, namely neurite outgrowth, and induction of neurofilament mRNA expression. Induction of proto-ret expression seemed to be correlated with neurite outgrowth and increase of neurofilament mRNA expression. These data suggest that the proto-ret product plays a role in neuronal differentiation.

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Year:  1991        PMID： 1766678

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  11 in total

Review 1.  Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.

Authors:  G Burzynski; I T Shepherd; H Enomoto
Journal:  Neurogastroenterol Motil       Date:  2009-02       Impact factor: 3.598

2.  A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos.

Authors:  R A Merrill; L A Plum; M E Kaiser; M Clagett-Dame
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

3.  Multiple actions of neurturin correlate with spatiotemporal patterns of Ret expression in developing chick cranial ganglion neurons.

Authors:  E Hashino; E M Johnson; J Milbrandt; M Shero; R J Salvi; C S Cohan
Journal:  J Neurosci       Date:  1999-10-01       Impact factor: 6.167

4.  No mutations found by RET mutation scanning in sporadic and hereditary neuroblastoma.

Authors:  R M Hofstra; N C Cheng; C Hansen; R P Stulp; T Stelwagen; N Clausen; N Tommerup; H Caron; A Westerveld; R Versteeg; C H Buys
Journal:  Hum Genet       Date:  1996-03       Impact factor: 4.132

5.  MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2/ASF).

Authors:  Salvador Meseguer; Giridhar Mudduluru; Juan Manuel Escamilla; Heike Allgayer; Domingo Barettino
Journal:  J Biol Chem       Date:  2010-11-30       Impact factor: 5.157

6.  Differential expression of RET isoforms in normal thyroid tissues, papillary and medullary thyroid carcinomas.

Authors:  Teresa Ramone; Cristina Romei; Raffaele Ciampi; Alessia Tacito; Paolo Piaggi; Liborio Torregrossa; Clara Ugolini; Rossella Elisei
Journal:  Endocrine       Date:  2019-07-05       Impact factor: 3.633

7.  Glucocorticoids differentially inhibit expression of the RET proto-oncogene.

Authors:  A Capes-Davis; S D Andrew; V J Hyland; S Twigg; D L Learoyd; T Dwight; D J Marsh; B G Robinson
Journal:  Gene Expr       Date:  1999

8.  Regulation of glial cell line-derived neurotrophic factor responsiveness in developing rat sympathetic neurons by retinoic acid and bone morphogenetic protein-2.

Authors:  S H Thang; M Kobayashi; I Matsuoka
Journal:  J Neurosci       Date:  2000-04-15       Impact factor: 6.167

9.  An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.

Authors:  M Santoro; W T Wong; P Aroca; E Santos; B Matoskova; M Grieco; A Fusco; P P di Fiore
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

10.  Expression of trkA cDNA in neuroblastomas mediates differentiation in vitro and in vivo.

Authors:  H Matsushima; E Bogenmann
Journal:  Mol Cell Biol       Date:  1993-12       Impact factor: 4.272
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