PURPOSE: To document and describe in detail the occurrence of apraxia of speech (AOS) in a group of individuals with a diagnosis of motor neuron disease (MND). METHOD: Seven individuals with MND and AOS were identified from among 80 patients with a variety of neurodegenerative diseases and AOS (J. R. Duffy, 2006). The history, presenting complaints, neurological findings, and speech-language findings were documented for each case. RESULTS: Spastic or mixed spastic-flaccid dysarthria was present in all 7 cases. The AOS was judged as worse than the dysarthria in 4 cases. Nonverbal oral apraxia was eventually present in all cases. Aphasia was present in 2 cases and equivocally present in another 2. Dementia was present in 1 case and equivocally present in 2. CONCLUSIONS: AOS can occur in MND, typically also with dysarthria, but not invariably with aphasia or other cognitive deficits. Thus, a diagnosis of MND does not preclude the presence of AOS. More importantly, MND should be a diagnostic consideration when AOS is a prominent sign of degenerative disease.
PURPOSE: To document and describe in detail the occurrence of apraxia of speech (AOS) in a group of individuals with a diagnosis of motor neuron disease (MND). METHOD: Seven individuals with MND and AOS were identified from among 80 patients with a variety of neurodegenerative diseases and AOS (J. R. Duffy, 2006). The history, presenting complaints, neurological findings, and speech-language findings were documented for each case. RESULTS:Spastic or mixed spastic-flaccid dysarthria was present in all 7 cases. The AOS was judged as worse than the dysarthria in 4 cases. Nonverbal oral apraxia was eventually present in all cases. Aphasia was present in 2 cases and equivocally present in another 2. Dementia was present in 1 case and equivocally present in 2. CONCLUSIONS:AOS can occur in MND, typically also with dysarthria, but not invariably with aphasia or other cognitive deficits. Thus, a diagnosis of MND does not preclude the presence of AOS. More importantly, MND should be a diagnostic consideration when AOS is a prominent sign of degenerative disease.
Authors: Alissa M Butts; Mary M Machulda; Joseph R Duffy; Edythe A Strand; Jennifer L Whitwell; Keith A Josephs Journal: J Int Neuropsychol Soc Date: 2015-06-11 Impact factor: 2.892
Authors: Tarun D Singh; Joseph R Duffy; Edythe A Strand; Mary M Machulda; Jennifer L Whitwell; Keith A Josephs Journal: Dement Geriatr Cogn Disord Date: 2015-01-21 Impact factor: 2.959
Authors: Keith A Josephs; Joseph R Duffy; Heather M Clark; Rene L Utianski; Edythe A Strand; Mary M Machulda; Hugo Botha; Peter R Martin; Nha Trang Thu Pham; Julie Stierwalt; Farwa Ali; Marina Buciuc; Matthew Baker; Cristhoper H Fernandez De Castro; Anthony J Spychalla; Christopher G Schwarz; Robert I Reid; Matthew L Senjem; Clifford R Jack; Val J Lowe; Eileen H Bigio; Ross R Reichard; Eric J Polley; Nilufer Ertekin-Taner; Rosa Rademakers; Michael A DeTure; Owen A Ross; Dennis W Dickson; Jennifer L Whitwell Journal: Nat Commun Date: 2021-06-08 Impact factor: 17.694
Authors: Jonathan D Rohrer; William D Knight; Jane E Warren; Nick C Fox; Martin N Rossor; Jason D Warren Journal: Brain Date: 2007-10-18 Impact factor: 13.501