BACKGROUND: The efficacy and safety of long-acting injectable risperidone have not been compared with those of an oral atypical antipsychotic. AIMS: To compare long-acting risperidone and oral olanzapine in 377 patients with DSM-IV schizophrenia or schizoaffective disorder. METHOD: Patients were randomised to receive long-acting risperidone (25 mg or 50 mg every 14 days) or olanzapine (5-20 mg/day). RESULTS: In the 13-week phase, long-acting risperidone was at least as effective as (not inferior to) oral olanzapine. In the 12-month phase, significant improvements in the Positive and Negative Syndrome Scale (PANSS) total and factor scores from baseline to month 12 and end-point were seen in both groups of patients. Few patients discontinued treatment because of an adverse event. CONCLUSIONS: Both treatments were efficacious and well tolerated.
RCT Entities:
BACKGROUND: The efficacy and safety of long-acting injectable risperidone have not been compared with those of an oral atypical antipsychotic. AIMS: To compare long-acting risperidone and oral olanzapine in 377 patients with DSM-IV schizophrenia or schizoaffective disorder. METHOD:Patients were randomised to receive long-acting risperidone (25 mg or 50 mg every 14 days) or olanzapine (5-20 mg/day). RESULTS: In the 13-week phase, long-acting risperidone was at least as effective as (not inferior to) oral olanzapine. In the 12-month phase, significant improvements in the Positive and Negative Syndrome Scale (PANSS) total and factor scores from baseline to month 12 and end-point were seen in both groups of patients. Few patients discontinued treatment because of an adverse event. CONCLUSIONS: Both treatments were efficacious and well tolerated.
Authors: Robert A Rosenheck; Douglas L Leslie; Kyaw J Sint; Haiqun Lin; Yue Li; Joseph P McEvoy; Matthew J Byerly; Robert M Hamer; Marvin S Swartz; T Scott Stroup Journal: Psychiatr Serv Date: 2016-06-01 Impact factor: 3.084
Authors: Kenneth L Subotnik; Laurie R Casaus; Joseph Ventura; John S Luo; Gerhard S Hellemann; Denise Gretchen-Doorly; Stephen Marder; Keith H Nuechterlein Journal: JAMA Psychiatry Date: 2015-08 Impact factor: 21.596
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Authors: Taishiro Kishimoto; Alfred Robenzadeh; Claudia Leucht; Stefan Leucht; Koichiro Watanabe; Masaru Mimura; Michael Borenstein; John M Kane; Christoph U Correll Journal: Schizophr Bull Date: 2012-12-17 Impact factor: 9.306
Authors: Brandon Abbs; Rashmin M Achalia; Adegoke O Adelufosi; Ahmet Yiğit Aktener; Natalie J Beveridge; Savita G Bhakta; Rachael K Blackman; Emre Bora; M S Byun; Maurice Cabanis; Ricardo Carrion; Christina A Castellani; Tze Jen Chow; M Dmitrzak-Weglarz; Charlotte Gayer-Anderson; Felipe V Gomes; Kristen Haut; Hiroaki Hori; Joshua T Kantrowitz; Taishiro Kishimoto; Frankie H F Lee; Ashleigh Lin; Lena Palaniyappan; Meina Quan; Maria D Rubio; Sonia Ruiz de Azúa; Saddichha Sahoo; Gregory P Strauss; Aleksandra Szczepankiewicz; Andrew D Thompson; Antonella Trotta; Laura M Tully; Hiroyuki Uchida; Eva Velthorst; Jared W Young; Anne O'Shea; Lynn E Delisi Journal: Schizophr Res Date: 2012-08-19 Impact factor: 4.939