Fast disintegrating tablets containing Rhodiola rosea L. extract.

Tablets with 250 mg of Rhodiola rosea L. extract disintegrating in less than 10 min were developed. The influence of the extract content and type of fillers and disintegrants on disintegration time and tablet hardness was evaluated. Type of the filler and the extract/filler ratio but not the type of disintegrant determined fast disintegration of the tablets. It was demonstrated that the extract:filler ratio lower than 1:1.5 enables preparation of tablets with the required disintegration time. The tablets containing microcrystalline cellulose as a filler, povidone as a binder and crospovidone as a disintegrant were stable during 6 months storage at 25 degrees C/60% RH, however, due to the decrease of hardness they did not pass the stability test at 40 degrees C/75% RH.