PURPOSE: This report was designed to discuss the case of a patient taking immunosuppression after transplant who developed squamous-cell carcinoma in a chronic pilonidal cyst and to examine the reported literature on malignant degeneration of pilonidal disease. METHODS: We performed a comprehensive literature review and examined the medical record of a patient taking immunosuppressive medications after renal transplant who developed squamous-cell carcinoma in a chronic pilonidal cyst located at the superior gluteal cleft. CONCLUSIONS: Pilonidal disease is a common condition, and it is important to know that malignancy can arise when the disease is chronic. Immunosuppression and human papillomavirus infection may be predisposing factors to malignant degeneration of pilonidal cysts and may accelerate the transformation.
PURPOSE: This report was designed to discuss the case of a patient taking immunosuppression after transplant who developed squamous-cell carcinoma in a chronic pilonidal cyst and to examine the reported literature on malignant degeneration of pilonidal disease. METHODS: We performed a comprehensive literature review and examined the medical record of a patient taking immunosuppressive medications after renal transplant who developed squamous-cell carcinoma in a chronic pilonidal cyst located at the superior gluteal cleft. CONCLUSIONS:Pilonidal disease is a common condition, and it is important to know that malignancy can arise when the disease is chronic. Immunosuppression and human papillomavirus infection may be predisposing factors to malignant degeneration of pilonidal cysts and may accelerate the transformation.
Authors: Styliani N Parpoudi; Dimitrios S Kyziridis; Dimitrios Ch Patridas; Apostolos N Makrantonakis; Pavlos Iosifidis; Ioannis G Mantzoros; Konstantinos C Tsalis Journal: Am J Case Rep Date: 2015-03-21
Authors: Sara Vertaldi; Pietro Anoldo; Grazia Cantore; Alessia Chini; Anna D'Amore; Maria D'Armiento; Nicola Gennarelli; Francesco Maione; Michele Manigrasso; Alessandra Marello; Pietro Schettino; Carmen Sorrentino; Loredana M Sosa Fernandez; Giovanni D De Palma; Marco Milone Journal: Front Surg Date: 2022-03-03