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Literature DB >> 17665199

[Quantitative methylation-specific PCR for the diagnosis of lung cancer].

H J Grote¹, V Schmiemann, M Kazimirek, A Böcking.

Abstract

Efficient, preferably early diagnosis of lung cancer represents a major challenge. Under this aspect the sensitivity of conventional histomorphology and cytomorphology procedures is unsatisfactory. This review highlights technical aspects, possibilities and drawbacks of the application of aberrant promoter methylation as a biomarker for lung cancer diagnostics using specimens of pulmonary exfoliative cytology.

Entities: Chemical

Mesh：

Substances：
Genetic Markers

Year: 2007 PMID： 17665199 DOI： 10.1007/s00292-007-0929-3

Source DB: PubMed Journal: Pathologe ISSN： 0172-8113 Impact factor: 0.973

31 in total

1. Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis.

Authors: Shuji Ogino; Takako Kawasaki; Mohan Brahmandam; Mami Cantor; Gregory J Kirkner; Donna Spiegelman; G Mike Makrigiorgos; Daniel J Weisenberger; Peter W Laird; Massimo Loda; Charles S Fuchs
Journal: J Mol Diagn Date: 2006-05 Impact factor: 5.568

2. Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study.

Authors: Viola Schmiemann; Alfred Böcking; Marietta Kazimirek; Alexandre Sherlley Casimiro Onofre; Helmut Erich Gabbert; Rainer Kappes; Claus Dieter Gerharz; Hans Juergen Grote
Journal: Clin Cancer Res Date: 2005-11-01 Impact factor: 12.531

Review 3. New developments in lung cancer screening.

Authors: James L Mulshine
Journal: J Clin Oncol Date: 2005-05-10 Impact factor: 44.544

Review 4. DNA methylation and epigenetic mechanisms.

Authors: R Holliday
Journal: Cell Biophys Date: 1989 Aug-Oct

5. Methylation of RAS association domain family protein 1A as a biomarker of lung cancer.

Authors: Hans Juergen Grote; Viola Schmiemann; Helene Geddert; Alfred Bocking; Rainer Kappes; Helmut Erich Gabbert; Mario Sarbia
Journal: Cancer Date: 2006-04-25 Impact factor: 6.860

6. Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer.

Authors: Ozlem Topaloglu; Mohammad Obaidul Hoque; Yutaka Tokumaru; Juna Lee; Edward Ratovitski; David Sidransky; Chul-so Moon
Journal: Clin Cancer Res Date: 2004-04-01 Impact factor: 12.531

[Quantitative methylation-specific PCR for the diagnosis of lung cancer].

1. Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis.

2. Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study.

Review 3. New developments in lung cancer screening.

Review 4. DNA methylation and epigenetic mechanisms.

5. Methylation of RAS association domain family protein 1A as a biomarker of lung cancer.

6. Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer.

7. A real-time PCR assay for DNA-methylation using methylation-specific blockers.

8. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

9. Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers.

10. DNA extraction from bronchial aspirates for molecular cytology: which method to take?

Review 1. [Preneoplastic lesions of pulmonary carcinoma].

2. Quantitative detection of TUSC3 promoter methylation -a potential biomarker for prognosis in lung cancer.