| Literature DB >> 17665110 |
An-Jie Dong1, Meng-Huang Feng, Hai-Ying Qi, Shan-Shan Li, Lian-Dong Deng.
Abstract
O-carboxymethyl chitosan/methoxy poly(ethylene glycol) graft copolymers (OCMCS-g-MPEGs) with different degrees of substitution (DS) were synthesized by reductive N-alkylation of chitosan with poly(ethylene glycol) aldehyde. The properties of OCMCS-g-MPEGs, including the solubility, structure, hydrodynamic behaviors, isoelectric point (IEP) and interaction with water-soluble chitosan, were investigated. As a PEGylated polyampholyte, OCMCS-g-MPEGs can resolve in water over all pH range and the pH value at IEP (pH(IEP)) decreases when DS increases. The hydrodynamic behaviors of OCMCS-g-MPEGs in deionized H(2)O are markedly affected by DS and pH(IEP) in the experiment concentration range. The particle size of the complexes of OCMCS-g-MPEGs with water-soluble chitosan is strongly affected by the concentration of water-soluble chitosan and the pH value.Entities:
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Year: 2007 PMID： 17665110 DOI： 10.1007/s10856-007-3183-6
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896