OBJECTIVE: We aimed to define the role of treatment using statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) in the management of patients with carotid artery disease. LITERATURE SEARCH METHODS: We searched PubMed for studies evaluating the effect of statins on carotid IMT and the occurrence of cerebrovascular events. LITERATURE SEARCH RESULTS: Current evidence indicates that routine statin therapy reduces carotid intima-media thickness progression and stroke risk. Additionally, statin treatment significantly reduces perioperative as well as long-term morbidity and mortality in patients undergoing carotid surgery or endovascular interventions. It would also be expected that statins would reduce coronary events in this high-risk population. CONCLUSIONS: Statins should be considered as an essential component of the therapeutic approach of patients with carotid artery stenosis.
OBJECTIVE: We aimed to define the role of treatment using statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) in the management of patients with carotid artery disease. LITERATURE SEARCH METHODS: We searched PubMed for studies evaluating the effect of statins on carotid IMT and the occurrence of cerebrovascular events. LITERATURE SEARCH RESULTS: Current evidence indicates that routine statin therapy reduces carotid intima-media thickness progression and stroke risk. Additionally, statin treatment significantly reduces perioperative as well as long-term morbidity and mortality in patients undergoing carotid surgery or endovascular interventions. It would also be expected that statins would reduce coronary events in this high-risk population. CONCLUSIONS: Statins should be considered as an essential component of the therapeutic approach of patients with carotid artery stenosis.
Authors: Alexander B Pothof; Emma S Zwanenburg; Sarah E Deery; Thomas F X O'Donnell; Gert J de Borst; Marc L Schermerhorn Journal: J Vasc Surg Date: 2017-10-23 Impact factor: 4.268
Authors: Michael Koutouzis; Kosmas I Paraskevas; Loukianos S Rallidis; Calypso Barbatis; Alexandros Nomikos; Vasiliki Tzavara; Maria Tsopanomichalou; Christos Lioupis; Nikolaos Bessias; Vassilios Andikopoulos; Dimitri P Mikhailidis; Zenon S Kyriakides Journal: Open Cardiovasc Med J Date: 2008-11-28