OBJECTIVE: Over-expression of annexin A2 (ANXA2) has been reported in various cancers. However, no data are available on the expression of this protein in head and neck squamous cell carcinomas (HNSCC). The objective of this preliminary study is to investigate the expression of ANXA2 in these carcinomas. MATERIAL AND METHOD: ANXA2 expression was analyzed by immunohistochemistry in paraffin-embedded sections from 9 patients with premalignant lesions and 21 patients with HNSCC. RESULTS: All dysplastic tissues showed significantly reduced ANXA2 expression compared to normal tissue. In contrast, ANXA2 expression was observed in all but one of the tumours studied. There was a significant correlation of lower ANXA2 expression with a poorer histological differentiation, larger tumours, and nodal metastases. CONCLUSIONS: Our data show for the first time that ANXA2 is expressed in head and neck squamous cell carcinomas and that its expression seems to be related with the degree of differentiation status of these tumours.
OBJECTIVE: Over-expression of annexin A2 (ANXA2) has been reported in various cancers. However, no data are available on the expression of this protein in head and neck squamous cell carcinomas (HNSCC). The objective of this preliminary study is to investigate the expression of ANXA2 in these carcinomas. MATERIAL AND METHOD:ANXA2 expression was analyzed by immunohistochemistry in paraffin-embedded sections from 9 patients with premalignant lesions and 21 patients with HNSCC. RESULTS: All dysplastic tissues showed significantly reduced ANXA2 expression compared to normal tissue. In contrast, ANXA2 expression was observed in all but one of the tumours studied. There was a significant correlation of lower ANXA2 expression with a poorer histological differentiation, larger tumours, and nodal metastases. CONCLUSIONS: Our data show for the first time that ANXA2 is expressed in head and neck squamous cell carcinomas and that its expression seems to be related with the degree of differentiation status of these tumours.
Authors: N Aktug Demir; S Kolgelier; S Sumer; A C Inkaya; S Ozcimen; L S Demir; O Ural; A Arpaci Journal: Eur J Clin Microbiol Infect Dis Date: 2014-05-23 Impact factor: 3.267
Authors: Jens K Habermann; Nana K Bündgen; Timo Gemoll; Sampsa Hautaniemi; Caroline Lundgren; Danny Wangsa; Jana Doering; Hans-Peter Bruch; Britta Nordstroem; Uwe J Roblick; Hans Jörnvall; Gert Auer; Thomas Ried Journal: Mol Cancer Date: 2011-10-31 Impact factor: 27.401
Authors: Chel Hun Choi; Joon-Yong Chung; Eun Joo Chung; John D Sears; Jeong-Won Lee; Duk-Soo Bae; Stephen M Hewitt Journal: BMC Cancer Date: 2016-07-11 Impact factor: 4.430