OBJECTIVE: To study the incidence and risk factors of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS: One hundred and forty-eight patients, undergoing formed HSCT at this institute from June 2003 to September 2004, were analyzed retrospectively according to the diagnostic criteria of IFI. RESULTS: Fifty-two cases of IFI were diagnosed, with 35 proven and 17 probable. The infection occurred a median of 62 days after HSCT and the cumulative incidence of proven IFI in 3 months, 6 months and one year after HSCT were 15.6%, 42.5% and 48.9% respectively. By multivariate analysis, the variable associated with early infection risk were severe acute graft-versus-host disease (GVHD), prolonged administration of broad spectrum antibiotics and cytomegalovirus infection, while chronic extensive GVHD and glucocorticosteroid use were associated with the late-onset IFI. CONCLUSION: Patients undergoing HSCT and having many risk factors are more likely predisposed to IFI, avoiding the risk factors might could reduce the incidence rate of IFI.
OBJECTIVE: To study the incidence and risk factors of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS: One hundred and forty-eight patients, undergoing formed HSCT at this institute from June 2003 to September 2004, were analyzed retrospectively according to the diagnostic criteria of IFI. RESULTS: Fifty-two cases of IFI were diagnosed, with 35 proven and 17 probable. The infection occurred a median of 62 days after HSCT and the cumulative incidence of proven IFI in 3 months, 6 months and one year after HSCT were 15.6%, 42.5% and 48.9% respectively. By multivariate analysis, the variable associated with early infection risk were severe acute graft-versus-host disease (GVHD), prolonged administration of broad spectrum antibiotics and cytomegalovirus infection, while chronic extensive GVHD and glucocorticosteroid use were associated with the late-onset IFI. CONCLUSION:Patients undergoing HSCT and having many risk factors are more likely predisposed to IFI, avoiding the risk factors might could reduce the incidence rate of IFI.
Authors: Yuqian Sun; He Huang; Jing Chen; Jianyong Li; Jun Ma; Juan Li; Yingmin Liang; Jianmin Wang; Yan Li; Kang Yu; Jianda Hu; Jie Jin; Chun Wang; Depei Wu; Yang Xiao; Xiaojun Huang Journal: Tumour Biol Date: 2014-10-08