| Literature DB >> 17663687 |
Tom V Adamkiewicz1, Paul Szabolcs, Ann Haight, K Scott Baker, Susan Staba, Amos Kedar, K Y Chiang, Lakshmanan Krishnamurti, Michael W Boyer, Joan Kurtzberg, John E Wagner, John R Wingard, Andrew M Yeager.
Abstract
UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n=5; 5/6 n=2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III-IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced-intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.Entities:
Mesh：
Year: 2007 PMID： 17663687 DOI： 10.1111/j.1399-3046.2007.00725.x
Source DB: PubMed Journal: Pediatr Transplant ISSN： 1397-3142