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Literature DB >> 17663448

Marine cytotoxic macrolides haterumalides and biselides, and related natural products.

Abstract

Marine animals and plants are rich sources of bioactive natural products. Haterumalides and biselides, isolated from Okinawan marine animals, are 14-membered macrolides with strong cytotoxicity against human cancer cell lines. This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2007 PMID： 17663448 DOI： 10.1002/tcr.20119

Source DB: PubMed Journal: Chem Rec ISSN： 1528-0691 Impact factor: 6.771

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Cited

8 in total

1. Synthesis of Unusually Strained Spiro Ring Systems and Their Exploits in Synthesis.

Authors: Richard J Duffy; Kay A Morris; Daniel Romo
Journal: Tetrahedron Date: 2009-09-01 Impact factor: 2.457

Review 2. Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads.

Authors: Eric W Schmidt; Mohamed S Donia
Journal: Curr Opin Biotechnol Date: 2010-11-01 Impact factor: 9.740

3. Asymmetric synthesis, structure, and reactivity of unexpectedly stable spiroepoxy-beta-lactones including facile conversion to tetronic acids: application to (+)-maculalactone A.

Authors: Richard J Duffy; Kay A Morris; Ravikrishna Vallakati; Wei Zhang; Daniel Romo
Journal: J Org Chem Date: 2009-07-03 Impact factor: 4.354

4. Total synthesis of haterumalides NA and NC via a chromium-mediated macrocyclization.

Authors: Jennifer M Schomaker; Babak Borhan
Journal: J Am Chem Soc Date: 2008-08-23 Impact factor: 15.419

5. Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq.

Authors: Miguel A Matilla; Finian J Leeper; George P C Salmond
Journal: Environ Microbiol Date: 2015-04-08 Impact factor: 5.491

Marine cytotoxic macrolides haterumalides and biselides, and related natural products.

1. Synthesis of Unusually Strained Spiro Ring Systems and Their Exploits in Synthesis.

Review 2. Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads.

3. Asymmetric synthesis, structure, and reactivity of unexpectedly stable spiroepoxy-beta-lactones including facile conversion to tetronic acids: application to (+)-maculalactone A.

4. Total synthesis of haterumalides NA and NC via a chromium-mediated macrocyclization.

5. Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq.

Review 6. The Tetrahydrofuran Motif in Polyketide Marine Drugs.

7. Chagosensine: A Riddle Wrapped in a Mystery Inside an Enigma.

8. A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones.