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Literature DB >> 17662717

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury.

Abstract

Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based therapies are becoming a therapeutic focus. This review will address the complexities and controversies of post-traumatic neuroinflammation, particularly in spinal cord. In addition, current therapies designed to target neuroinflammatory cascades will be discussed.

Entities: Disease

Mesh：

Year: 2007 PMID： 17662717 PMCID： PMC2692462 DOI： 10.1016/j.expneurol.2007.06.009

Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330

188 in total

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Journal: Neuroscientist Date: 2002-10 Impact factor: 7.519

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359 in total

Review 1. Biomaterial Approaches to Modulate Reactive Astroglial Response.

Authors: Jonathan M Zuidema; Ryan J Gilbert; Manoj K Gottipati
Journal: Cells Tissues Organs Date: 2018-12-05 Impact factor: 2.481

2. IT delivery of ChABC modulates NG2 and promotes GAP-43 axonal regrowth after spinal cord injury.

Authors: I Novotna; L Slovinska; I Vanicky; M Cizek; J Radonak; D Cizkova
Journal: Cell Mol Neurobiol Date: 2011-06-01 Impact factor: 5.046

3. The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice.

Authors: Akshata Almad; A Todd Lash; Ping Wei; Amy E Lovett-Racke; Dana M McTigue
Journal: Exp Neurol Date: 2011-09-21 Impact factor: 5.330

4. The relationship between localized subarachnoid inflammation and parenchymal pathophysiology after spinal cord injury.

Authors: James W Austin; Mehdi Afshar; Michael G Fehlings
Journal: J Neurotrauma Date: 2012-07-01 Impact factor: 5.269

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Authors: Nassir Mokarram; Ravi V Bellamkonda
Journal: IEEE Trans Biomed Eng Date: 2010-12-30 Impact factor: 4.538

6. Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage.

Authors: Jonghyuck Park; Lingxing Zheng; Andrew Marquis; Michael Walls; Brad Duerstock; Amber Pond; Sasha Vega-Alvarez; He Wang; Zheng Ouyang; Riyi Shi
Journal: J Neurochem Date: 2013-12-15 Impact factor: 5.372

Review 7. Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair.

Authors: Inés Maldonado-Lasunción; Joost Verhaagen; Martin Oudega
Journal: Neurotherapeutics Date: 2018-07 Impact factor: 7.620

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9. A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury.

Authors: Nishanth Lakshman; Wenjun Xu; Cindi M Morshead
Journal: J Vis Exp Date: 2018-09-13 Impact factor: 1.355

10. Fibronectin Matrix Assembly after Spinal Cord Injury.

Authors: Yunjiao Zhu; Cynthia Soderblom; Michelle Trojanowsky; Do-Hun Lee; Jae K Lee
Journal: J Neurotrauma Date: 2015-03-09 Impact factor: 5.269