| Literature DB >> 17662603 |
Bryan H Norman1, Timothy I Richardson, Jeffrey A Dodge, Lance A Pfeifer, Gregory L Durst, Yong Wang, Jim D Durbin, Venkatesh Krishnan, Sean R Dinn, Shengquan Liu, John E Reilly, Kendal T Ryter.
Abstract
Benzopyrans are selective estrogen receptor (ER) beta agonists (SERBAs), which bind the ER receptor subtypes alpha and beta in opposite orientations. We have used structure based drug design to show that this unique phenomena can be exploited via substitution at the 8-position of the benzopyran A-ring to disrupt binding to ERalpha, thus improving ERbeta subtype selectivity. X-ray cocrystal structures with ERalpha and ERbeta are supportive of this approach to improve selectivity in this structural class.Entities:
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Year: 2007 PMID： 17662603 DOI： 10.1016/j.bmcl.2007.07.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823