| Literature DB >> 17660585 |
M Novakova1, V Bruderova, Z Sulova, J Kopacek, L Lacinova, R Kvetnansky, A Vasku, P Kaplan, O Krizanova, D Jurkovicova.
Abstract
The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptor's mRNA levels. Signalling cascade of sigma receptors is dependent on IP(3) receptors, since silencing of both, type 1 and 2 IP(3) receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes.Entities:
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Year: 2007 PMID： 17660585
Source DB: PubMed Journal: Gen Physiol Biophys ISSN： 0231-5882 Impact factor: 1.512