| Literature DB >> 17659761 |
Andrea Marzi1, Daniel A Mitchell, Chawaree Chaipan, Tanja Fisch, Robert W Doms, Mary Carrington, Ronald C Desrosiers, Stefan Pöhlmann.
Abstract
The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.Entities:
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Year: 2007 PMID： 17659761 DOI： 10.1016/j.virol.2007.07.004
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616