AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer. METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma. RESULTS: Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively. CONCLUSION: A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.
AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer. METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma. RESULTS: Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively. CONCLUSION: A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.
Authors: A Vecchione; H Ishii; Y H Shiao; F Trapasso; M Rugge; J F Tamburrino; Y Murakumo; H Alder; C M Croce; R Baffa Journal: Clin Cancer Res Date: 2001-06 Impact factor: 12.531
Authors: H Ishii; R Baffa; S I Numata; Y Murakumo; S Rattan; H Inoue; M Mori; V Fidanza; H Alder; C M Croce Journal: Proc Natl Acad Sci U S A Date: 1999-03-30 Impact factor: 11.205
Authors: Lindsay M Morton; Maryjean Schenk; David W Hein; Scott Davis; Shelia Hoar Zahm; Wendy Cozen; James R Cerhan; Patricia Hartge; Robert Welch; Stephen J Chanock; Nathaniel Rothman; Sophia S Wang Journal: Pharmacogenet Genomics Date: 2006-08 Impact factor: 2.089
Authors: James M Flanagan; Sue Healey; Joanne Young; Vicki Whitehall; Deborah A Trott; Robert F Newbold; Georgia Chenevix-Trench Journal: Genes Chromosomes Cancer Date: 2004-07 Impact factor: 5.006