PURPOSE: To implement proton magnetic resonance spectroscopic imaging (1H MRSI) at 3 Tesla (3T) using an eight-channel phased-array head coil in a population of brain-tumor patients. MATERIALS AND METHODS: A total of 49 MRI/MRSI examinations were performed on seven volunteers and 34 patients on a 3T GE Signa EXCITE scanner using body coil excitation and reception with an eight-channel phased-array head coil. 1H MRSI was acquired using point-resolved spectroscopy (PRESS) volume selection and three-dimensional (3D) phase encoding using a 144-msec echo time (TE). RESULTS: The mean choline to N-acetyl aspartate ratio (Cho/NAA) was similar within regions of normal-appearing white matter (NAWM) in volunteers (0.5 +/- 0.04) and patients (0.6 +/- 0.1, P = 0.15). This ratio was significantly higher in regions of T2-hyperintensity lesion (T2L) relative to NAWM for patients (1.4 +/- 0.7, P = 0.001). The differences between metabolite intensities in lesions and NAWM were similar, but there was an increase in SNR of 1.95 when an eight-channel head coil was used at 3T vs. previous results at 1.5T. CONCLUSION: The realized increase in SNR means that clinically relevant data can be obtained in five to 10 minutes at 3T and used to predict the spatial extent of tumor in a manner similar to that previously used to acquire 1.5T data in 17 minutes. Copyright 2007 Wiley-Liss, Inc.
PURPOSE: To implement proton magnetic resonance spectroscopic imaging (1H MRSI) at 3 Tesla (3T) using an eight-channel phased-array head coil in a population of brain-tumorpatients. MATERIALS AND METHODS: A total of 49 MRI/MRSI examinations were performed on seven volunteers and 34 patients on a 3T GE Signa EXCITE scanner using body coil excitation and reception with an eight-channel phased-array head coil. 1H MRSI was acquired using point-resolved spectroscopy (PRESS) volume selection and three-dimensional (3D) phase encoding using a 144-msec echo time (TE). RESULTS: The mean choline to N-acetyl aspartate ratio (Cho/NAA) was similar within regions of normal-appearing white matter (NAWM) in volunteers (0.5 +/- 0.04) and patients (0.6 +/- 0.1, P = 0.15). This ratio was significantly higher in regions of T2-hyperintensity lesion (T2L) relative to NAWM for patients (1.4 +/- 0.7, P = 0.001). The differences between metabolite intensities in lesions and NAWM were similar, but there was an increase in SNR of 1.95 when an eight-channel head coil was used at 3T vs. previous results at 1.5T. CONCLUSION: The realized increase in SNR means that clinically relevant data can be obtained in five to 10 minutes at 3T and used to predict the spatial extent of tumor in a manner similar to that previously used to acquire 1.5T data in 17 minutes. Copyright 2007 Wiley-Liss, Inc.
Authors: David A Hormuth; Anna G Sorace; John Virostko; Richard G Abramson; Zaver M Bhujwalla; Pedro Enriquez-Navas; Robert Gillies; John D Hazle; Ralph P Mason; C Chad Quarles; Jared A Weis; Jennifer G Whisenant; Junzhong Xu; Thomas E Yankeelov Journal: J Magn Reson Imaging Date: 2019-03-29 Impact factor: 4.813
Authors: Esin Ozturk-Isik; Albert P Chen; Jason C Crane; Wei Bian; Duan Xu; Eric T Han; Susan M Chang; Daniel B Vigneron; Sarah J Nelson Journal: Magn Reson Imaging Date: 2009-09-19 Impact factor: 2.546
Authors: Matthew L Zierhut; Esin Ozturk-Isik; Albert P Chen; Ilwoo Park; Daniel B Vigneron; Sarah J Nelson Journal: J Magn Reson Imaging Date: 2009-09 Impact factor: 4.813
Authors: Joseph A Osorio; Duan Xu; Charles H Cunningham; Albert Chen; Adam B Kerr; John M Pauly; Daniel B Vigneron; Sarah J Nelson Journal: Magn Reson Med Date: 2009-03 Impact factor: 4.668
Authors: Sanjeev Chawla; Sumei Wang; Peachie Moore; John H Woo; Lauren Elman; Leo F McCluskey; Elias R Melhem; Murray Grossman; Harish Poptani Journal: J Neurol Date: 2009-08-18 Impact factor: 4.849