Antoine Abu-Musa1, Ihab Usta2, Anwar Nassar2, Fatiha Hajami2, Antoine Hannoun2. 1. Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: aa06@aub.edu.lb. 2. Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.
Abstract
OBJECTIVE: To assess the effect of 17alpha-hydroxyprogesterone caproate (17-HPC) given before embryo transfer on the pregnancy outcome of IVF-embryo transfer (ET) cycles. DESIGN: Randomized controlled study. SETTING: A university-based hospital IVF unit. PATIENT(S): One hundred twenty-five consecutive patients undergoing IVF-ET were randomly assigned into treatment and control groups. INTERVENTION(S): In the treatment group, 63 patients received 17-HPC (250 mg, i.m.), 1 day before ET. The control group consisted of 62 patients who did not receive any injections. MAIN OUTCOME MEASURE(S): Pregnancy and multiple-pregnancy rates. RESULT(S): The two groups were similar with respect to the age of patients, total dose of FSH, number of oocytes and embryos obtained, and number and quality of embryos transferred. There was no significant difference in the pregnancy rate (34.9% vs. 38.7%) or in the rate of multiple gestation (15.9% vs. 9.7%) between cases and controls, respectively. CONCLUSION(S): The use of 17-HPC before ET does not appear to affect the outcome of IVF-ET.
RCT Entities:
OBJECTIVE: To assess the effect of 17alpha-hydroxyprogesterone caproate (17-HPC) given before embryo transfer on the pregnancy outcome of IVF-embryo transfer (ET) cycles. DESIGN: Randomized controlled study. SETTING: A university-based hospital IVF unit. PATIENT(S): One hundred twenty-five consecutive patients undergoing IVF-ET were randomly assigned into treatment and control groups. INTERVENTION(S): In the treatment group, 63 patients received 17-HPC (250 mg, i.m.), 1 day before ET. The control group consisted of 62 patients who did not receive any injections. MAIN OUTCOME MEASURE(S): Pregnancy and multiple-pregnancy rates. RESULT(S): The two groups were similar with respect to the age of patients, total dose of FSH, number of oocytes and embryos obtained, and number and quality of embryos transferred. There was no significant difference in the pregnancy rate (34.9% vs. 38.7%) or in the rate of multiple gestation (15.9% vs. 9.7%) between cases and controls, respectively. CONCLUSION(S): The use of 17-HPC before ET does not appear to affect the outcome of IVF-ET.
Authors: Matthew T Connell; Jennifer M Szatkowski; Nancy Terry; Alan H DeCherney; Anthony M Propst; Micah J Hill Journal: Fertil Steril Date: 2015-01-29 Impact factor: 7.329
Authors: Michelle van der Linden; Karen Buckingham; Cindy Farquhar; Jan A M Kremer; Mostafa Metwally Journal: Cochrane Database Syst Rev Date: 2015-07-07