Literature DB >> 17658467

Plasmid encoded neurotoxin genes in Clostridium botulinum serotype A subtypes.

Kristin M Marshall1, Marite Bradshaw, Sabine Pellett, Eric A Johnson.   

Abstract

Clostridium botulinum, an important pathogen of humans and animals, produces botulinum neurotoxin (BoNT), the most poisonous toxin known. We have determined by pulsed-field gel electrophoresis (PFGE) and Southern hybridizations that the genes encoding BoNTs in strains Loch Maree (subtype A3) and 657Ba (type B and subtype A4) are located on large (approximately 280 kb) plasmids. This is the first demonstration of plasmid-borne neurotoxin genes in Clostridium botulinum serotypes A and B. The finding of BoNT type A and B genes on extrachromosomal elements has important implications for the evolution of neurotoxigenicity in clostridia including the origin, expression, and lateral transfer of botulinum neurotoxin genes.

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Year:  2007        PMID： 17658467      PMCID： PMC2346372          DOI： 10.1016/j.bbrc.2007.06.166

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


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