Literature DB >> 17655910

Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis.

Yan Liu1, Li Fu, Ding-Geng Chen, Samir S Deeb.   

Abstract

Using the human WERI-Rb1 cell line as a model system, we performed a genome-wide search for retinal target genes of thyroid hormone (TH) via expression microarray analysis followed by quantitative real-time RT-PCR verification. We identified 12 novel retinal targets of TH, including 10 up-regulated genes (OPN1MW, OPN1LW, TIMP3, RP1L1, GNGT2, CRX, ARR3, GCAP1, IMPDH1, and PDE6C) and 2 down-regulated genes (GNGT1 and GNB3). In addition, we found a number of novel TH-targets that are not currently known to be retinal genes. This is the first report of human retinal targets regulated by thyroid hormone.

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Year:  2007        PMID： 17655910      PMCID： PMC2932699          DOI： 10.1016/j.visres.2007.04.023

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  38 in total

1.  Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function.

Authors:  A Swaroop; Q L Wang; W Wu; J Cook; C Coats; S Xu; S Chen; D J Zack; P A Sieving
Journal:  Hum Mol Genet       Date:  1999-02       Impact factor: 6.150

2.  Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog.

Authors:  C C Thompson
Journal:  J Neurosci       Date:  1996-12-15       Impact factor: 6.167

3.  Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation.

Authors:  T Furukawa; E M Morrow; C L Cepko
Journal:  Cell       Date:  1997-11-14       Impact factor: 41.582

4.  Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes.

Authors:  S Chen; Q L Wang; Z Nie; H Sun; G Lennon; N G Copeland; D J Gilbert; N A Jenkins; D J Zack
Journal:  Neuron       Date:  1997-11       Impact factor: 17.173

5.  Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor.

Authors:  C L Freund; C Y Gregory-Evans; T Furukawa; M Papaioannou; J Looser; L Ploder; J Bellingham; D Ng; J A Herbrick; A Duncan; S W Scherer; L C Tsui; A Loutradis-Anagnostou; S G Jacobson; C L Cepko; S S Bhattacharya; R R McInnes
Journal:  Cell       Date:  1997-11-14       Impact factor: 41.582

6.  Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration.

Authors:  P K Swain; S Chen; Q L Wang; L M Affatigato; C L Coats; K D Brady; G A Fishman; S G Jacobson; A Swaroop; E Stone; P A Sieving; D J Zack
Journal:  Neuron       Date:  1997-12       Impact factor: 17.173

7.  Serological reactivity of recombinant 1D autoantigen and its expression in human thyroid and eye muscle tissue: a possible autoantigenic link in Graves' patients.

Authors:  A Kromminga; C Hagel; R Arndt; F Schuppert
Journal:  J Clin Endocrinol Metab       Date:  1998-08       Impact factor: 5.958

8.  Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy.

Authors:  B H Weber; G Vogt; R C Pruett; H Stöhr; U Felbor
Journal:  Nat Genet       Date:  1994-12       Impact factor: 38.330

9.  Increased expression of retinal TIMP3 mRNA in simplex retinitis pigmentosa is localized to photoreceptor-retaining regions.

Authors:  C Jomary; M J Neal; S E Jones
Journal:  J Neurochem       Date:  1995-05       Impact factor: 5.372

10.  Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby's fundus dystrophy or retinitis pigmentosa.

Authors:  R N Fariss; S S Apte; P J Luthert; A C Bird; A H Milam
Journal:  Br J Ophthalmol       Date:  1998-11       Impact factor: 4.638
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  17 in total

1.  Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.

Authors:  Ailing Lu; Lily Ng; Michelle Ma; Benjamin Kefas; Terry F Davies; Arturo Hernandez; Chi-Chao Chan; Douglas Forrest
Journal:  Endocrinology       Date:  2008-10-30       Impact factor: 4.736

Review 2.  Minireview: the role of nuclear receptors in photoreceptor differentiation and disease.

Authors:  Douglas Forrest; Anand Swaroop
Journal:  Mol Endocrinol       Date:  2012-05-03

3.  Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration.

Authors:  Hongwei Ma; Fan Yang; Michael R Butler; Joshua Belcher; T Michael Redmond; Andrew T Placzek; Thomas S Scanlan; Xi-Qin Ding
Journal:  FASEB J       Date:  2017-04-20       Impact factor: 5.191

4.  Light-Regulated Thyroid Hormone Signaling Is Required for Rod Photoreceptor Development in the Mouse Retina.

Authors:  Onkar Sawant; Amanda M Horton; Meenal Shukla; Mary E Rayborn; Neal S Peachey; Joe G Hollyfield; Sujata Rao
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-12       Impact factor: 4.799

5.  The effect of hypothyroidism on color contrast sensitivity: a prospective study.

Authors:  Mehtap Cakir; Banu Turgut Ozturk; Elif Turan; Gulsum Gonulalan; Ilker Polat; Kemal Gunduz
Journal:  Eur Thyroid J       Date:  2015-02-07

6.  Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration.

Authors:  Fan Yang; Hongwei Ma; Joshua Belcher; Michael R Butler; T Michael Redmond; Sanford L Boye; William W Hauswirth; Xi-Qin Ding
Journal:  FASEB J       Date:  2016-09-13       Impact factor: 5.191

7.  Transcriptional profiling of fibroblasts from patients with mutations in MCT8 and comparative analysis with the human brain transcriptome.

Authors:  W Edward Visser; Sigrid M A Swagemakers; Zeliha Ozgur; Rachel Schot; Frans W Verheijen; Wilfred F J van Ijcken; Peter J van der Spek; Theo J Visser
Journal:  Hum Mol Genet       Date:  2010-08-12       Impact factor: 6.150

Review 8.  Mechanisms of Photoreceptor Patterning in Vertebrates and Invertebrates.

Authors:  Kayla Viets; Kiara Eldred; Robert J Johnston
Journal:  Trends Genet       Date:  2016-10       Impact factor: 11.639

9.  Potential contribution of ryanodine receptor 2 upregulation to cGMP/PKG signaling-induced cone degeneration in cyclic nucleotide-gated channel deficiency.

Authors:  Fan Yang; Hongwei Ma; Michael R Butler; Xi-Qin Ding
Journal:  FASEB J       Date:  2020-03-16       Impact factor: 5.191

10.  The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation.

Authors:  L-F Wang; Y-S Liu; B Yang; P Li; X-S Cheng; C-X Xiao; J-J Liu; S Li; J-L Ren; B Guleng
Journal:  Oncogene       Date:  2017-10-09       Impact factor: 9.867
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