BACKGROUND: Dedifferentiated chondrosarcoma represents a special form of the chondrosarcoma characterized by the presence of well-differentiated cartilaginous component in juxtaposition with the malignant mesenchymal tumor of high-malignancy grade. METHODS: The study was performed on 25 tissue samples obtained by biopsy of the primary malignant bone tumors. RESULTS: Out of the total of 25 patients, 13 were males and 12 were females. Their average age was 59.9 years (39-75). Radiological examination verified the presence of the pathological fractures in 14 patients. The skeletal distribution clearly indicates that the femur is the most frequent site of affection (in 15 patients--60%). Morphological analysis verified the presence of "precursor cartilaginous lesion" or low-grade cartilaginous component in all cases. Classification of the high-grade components was based on the immunohistochemical analyses, which evidenced MFH in 18 cases, osteosarcoma in 4, while fibrosarcoma was evidenced in 2 and rhabdomyosarcoma in 1 case. In 20 patients, out of whom 14 had existing fractures, amputation was indicated. In five patients (fracture-free), resection limb-salvage surgical intervention was performed. CONCLUSION: The lethal outcome ensues within less than 2 years in all patients.
BACKGROUND: Dedifferentiated chondrosarcoma represents a special form of the chondrosarcoma characterized by the presence of well-differentiated cartilaginous component in juxtaposition with the malignant mesenchymal tumor of high-malignancy grade. METHODS: The study was performed on 25 tissue samples obtained by biopsy of the primary malignant bone tumors. RESULTS: Out of the total of 25 patients, 13 were males and 12 were females. Their average age was 59.9 years (39-75). Radiological examination verified the presence of the pathological fractures in 14 patients. The skeletal distribution clearly indicates that the femur is the most frequent site of affection (in 15 patients--60%). Morphological analysis verified the presence of "precursor cartilaginous lesion" or low-grade cartilaginous component in all cases. Classification of the high-grade components was based on the immunohistochemical analyses, which evidenced MFH in 18 cases, osteosarcoma in 4, while fibrosarcoma was evidenced in 2 and rhabdomyosarcoma in 1 case. In 20 patients, out of whom 14 had existing fractures, amputation was indicated. In five patients (fracture-free), resection limb-salvage surgical intervention was performed. CONCLUSION: The lethal outcome ensues within less than 2 years in all patients.
Authors: A Sakamoto; Y Oda; T Adachi; Y Oshiro; S Tamiya; K Tanaka; S Matsuda; Y Iwamoto; M Tsuneyoshi Journal: Mod Pathol Date: 2001-04 Impact factor: 7.842
Authors: Judith V M G Bovée; Anne-Marie Cleton-Jansen; Antonie H M Taminiau; Pancras C W Hogendoorn Journal: Lancet Oncol Date: 2005-08 Impact factor: 41.316
Authors: Ian D Dickey; Peter S Rose; Bruno Fuchs; Lester E Wold; Scott H Okuno; Franklin H Sim; Sean P Scully Journal: J Bone Joint Surg Am Date: 2004-11 Impact factor: 5.284
Authors: Richard F Riedel; Nicole Larrier; Leslie Dodd; David Kirsch; Salutario Martinez; Brian E Brigman Journal: Curr Treat Options Oncol Date: 2009-02-24