OBJECTIVE: The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss. The aim of the present study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. METHODS: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score < or =-1.28 at either the hip or spine) or high BMD (Z score > or =+1). Single locus and haplotype associations were performed using logistic regression with adjustment of age, height and weight. RESULTS: The variant 'G' allele of rs2619112 was associated with a reduced risk of low BMD at the femoral neck in pre-menopausal women (OR = 0.442, p = 0.007) but an increased risk in post-menopausal women (OR = 1.727, p = 0.042). Haplotype analysis revealed findings similar to the single locus tests. CONCLUSION: The variant alleles of rs2619112 and rs916055 and their haplotypes of ALOX15 are associated with high BMD in pre-menopausal women but low BMD in post-menopausal women. This suggests that ALOX15 is a dual modulator of BMD variation with opposing effects in pre- and post-menopausal women. Copyright 2008 S. Karger AG, Basel.
OBJECTIVE: The 12/15-lipoxygenase gene ALOX15 is reported to be a negative regulator of BMD in knockout mice. Nonetheless results are controversial as over-expression of ALOX15 protects against inflammation-related bone loss. The aim of the present study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. METHODS: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score < or =-1.28 at either the hip or spine) or high BMD (Z score > or =+1). Single locus and haplotype associations were performed using logistic regression with adjustment of age, height and weight. RESULTS: The variant 'G' allele of rs2619112 was associated with a reduced risk of low BMD at the femoral neck in pre-menopausal women (OR = 0.442, p = 0.007) but an increased risk in post-menopausal women (OR = 1.727, p = 0.042). Haplotype analysis revealed findings similar to the single locus tests. CONCLUSION: The variant alleles of rs2619112 and rs916055 and their haplotypes of ALOX15 are associated with high BMD in pre-menopausal women but low BMD in post-menopausal women. This suggests that ALOX15 is a dual modulator of BMD variation with opposing effects in pre- and post-menopausal women. Copyright 2008 S. Karger AG, Basel.
Authors: Gregory J Tranah; Brent C Taylor; Li-Yung Lui; Joseph M Zmuda; Jane A Cauley; Kristine E Ensrud; Teresa A Hillier; Marc C Hochberg; Jia Li; Brian K Rhees; Henry A Erlich; Mark D Sternlicht; Gary Peltz; Steven R Cummings Journal: Calcif Tissue Int Date: 2008-09-12 Impact factor: 4.333
Authors: Sarah E Kleinstein; Laura Heath; Karen W Makar; Elizabeth M Poole; Brenna L Seufert; Martha L Slattery; Liren Xiao; David J Duggan; Li Hsu; Karen Curtin; Lisel Koepl; Jill Muehling; Darin Taverna; Bette J Caan; Christopher S Carlson; John D Potter; Cornelia M Ulrich Journal: Genes Chromosomes Cancer Date: 2013-02-12 Impact factor: 5.006
Authors: Cheryl L Ackert-Bicknell; David Karasik; Qian Li; Randy V Smith; Yi-Hsiang Hsu; Gary A Churchill; Beverly J Paigen; Shirng-Wern Tsaih Journal: J Bone Miner Res Date: 2010-08 Impact factor: 6.741