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Literature DB >> 17652810

Anthracycline-induced phospholipase A2 inhibition.

Luther Swift¹, Jane McHowat, Narine Sarvazyan.

Abstract

The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2 is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of the early culprits leading to anthracycline-induced cardiac dysfunction. The clinical importance and potential pharmaceutical use of this new phenomenon await further studies.

Entities: Chemical Disease Gene

Mesh：

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Year: 2007 PMID： 17652810 PMCID： PMC3031855 DOI： 10.1007/s12012-007-0012-6

Source DB: PubMed Journal: Cardiovasc Toxicol ISSN： 1530-7905 Impact factor: 3.231

26 in total

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4 in total

1. Anthracycline cardiotoxicity: from bench to bedside.

Authors: Luca Gianni; Eugene H Herman; Steven E Lipshultz; Giorgio Minotti; Narine Sarvazyan; Douglas B Sawyer
Journal: J Clin Oncol Date: 2008-08-01 Impact factor: 44.544

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Authors: Giorgio Minotti; Narine Sarvazyan
Journal: Cardiovasc Toxicol Date: 2007 Impact factor: 3.231

3. Inhibition of iPLA2 β and of stretch-activated channels by doxorubicin alters dystrophic muscle function.

Authors: H M Ismail; O M Dorchies; R Perozzo; M K Strosova; L Scapozza; U T Ruegg
Journal: Br J Pharmacol Date: 2013-08 Impact factor: 8.739

4. Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines.

Authors: Olga H Toro-Salazar; Ji Hyun Lee; Kia N Zellars; Paige E Perreault; Kathryn C Mason; Zhu Wang; Kan N Hor; Eileen Gillan; Caroline J Zeiss; Daniel M Gatti; Brooke T Davey; Shelby Kutty; Bruce T Liang; Francis G Spinale
Journal: Cardiooncology Date: 2018-05-01

4 in total